The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore, great therapeutic benefits can be attai...

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Autores principales:	El-Shaimaa A. Arafa, Mohamed S. Refaey, Omnia A.M. Abd El-Ghafar, Emad H.M. Hassanein, Ahmed M. Sayed
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ginsenosides MAPK Apoptosis anti-inflammatory Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/b1b5b0144f7b4a2ca871e63d31576984
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spelling	oai:doaj.org-article:b1b5b0144f7b4a2ca871e63d315769842021-12-02T05:02:48ZThe promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition2405-844010.1016/j.heliyon.2021.e08354https://doaj.org/article/b1b5b0144f7b4a2ca871e63d315769842021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024579https://doaj.org/toc/2405-8440The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore, great therapeutic benefits can be attained from p38 MAPK inhibitors. Ginseng is an exceptionally valued medicinal plant of the family Araliaceae (Panax genus). Recently, several studies targeted the therapeutic effects of purified individual ginsenoside, the most significant active ingredient of ginseng, and studied its particular molecular mechanism(s) of action rather than whole-plant extracts. Interestingly, several ginsenosides: ginsenosides compound K, F1, Rb1, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Rg5, Rh1, Rh2, Ro, notoginsenoside R1, and protopanaxadiol have shown to possess great therapeutic potentials mediated by their ability to downregulate p38 MAPK signaling in different cell lines and experimental animal models. Our review compiles the research findings of various ginsenosides as potent anti-inflammatory agents, highlighting the crucial role of p38 MAPK suppression in their pharmacological actions. In addition, in silico studies were conducted to explore the probable binding of these ginsenosides to p38 MAPK. The results obtained proposed p38 MAPK involvement in the beneficial pharmacological activities of ginsenosides in different ailments.El-Shaimaa A. ArafaMohamed S. RefaeyOmnia A.M. Abd El-GhafarEmad H.M. HassaneinAhmed M. SayedElsevierarticleGinsenosidesMAPKApoptosisanti-inflammatoryScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08354- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ginsenosides MAPK Apoptosis anti-inflammatory Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Ginsenosides MAPK Apoptosis anti-inflammatory Science (General) Q1-390 Social sciences (General) H1-99 El-Shaimaa A. Arafa Mohamed S. Refaey Omnia A.M. Abd El-Ghafar Emad H.M. Hassanein Ahmed M. Sayed The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
description	The p38 mitogen-activated protein kinases (p38 MAPK) is a 38kD polypeptide recognized as the target for many potential anti-inflammatory agents. Accumulating evidence indicates that p38 MAPK could perform many roles in human disease pathophysiology. Therefore, great therapeutic benefits can be attained from p38 MAPK inhibitors. Ginseng is an exceptionally valued medicinal plant of the family Araliaceae (Panax genus). Recently, several studies targeted the therapeutic effects of purified individual ginsenoside, the most significant active ingredient of ginseng, and studied its particular molecular mechanism(s) of action rather than whole-plant extracts. Interestingly, several ginsenosides: ginsenosides compound K, F1, Rb1, Rb3, Rc, Rd, Re, Rf, Rg1, Rg2, Rg3, Rg5, Rh1, Rh2, Ro, notoginsenoside R1, and protopanaxadiol have shown to possess great therapeutic potentials mediated by their ability to downregulate p38 MAPK signaling in different cell lines and experimental animal models. Our review compiles the research findings of various ginsenosides as potent anti-inflammatory agents, highlighting the crucial role of p38 MAPK suppression in their pharmacological actions. In addition, in silico studies were conducted to explore the probable binding of these ginsenosides to p38 MAPK. The results obtained proposed p38 MAPK involvement in the beneficial pharmacological activities of ginsenosides in different ailments.
format	article
author	El-Shaimaa A. Arafa Mohamed S. Refaey Omnia A.M. Abd El-Ghafar Emad H.M. Hassanein Ahmed M. Sayed
author_facet	El-Shaimaa A. Arafa Mohamed S. Refaey Omnia A.M. Abd El-Ghafar Emad H.M. Hassanein Ahmed M. Sayed
author_sort	El-Shaimaa A. Arafa
title	The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
title_short	The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
title_full	The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
title_fullStr	The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
title_full_unstemmed	The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition
title_sort	promising therapeutic potentials of ginsenosides mediated through p38 mapk signaling inhibition
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b1b5b0144f7b4a2ca871e63d31576984
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The promising therapeutic potentials of ginsenosides mediated through p38 MAPK signaling inhibition

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