Plato's cave algorithm: inferring functional signaling networks from early gene expression shadows.

Improving the ability to reverse engineer biochemical networks is a major goal of systems biology. Lesions in signaling networks lead to alterations in gene expression, which in principle should allow network reconstruction. However, the information about the activity levels of signaling proteins co...

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Auteurs principaux: Yishai Shimoni, Marc Y Fink, Soon-gang Choi, Stuart C Sealfon
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2010
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Accès en ligne:https://doaj.org/article/b1b652f6d60c4a7aafb8189bc7f47a3e
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