PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regulator C/EBPβ.
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Nature Portfolio
2019
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oai:doaj.org-article:b1b8d976c5c54a27ab395cced065f0c02021-12-02T17:01:44ZPAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer10.1038/s41467-019-11510-42041-1723https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c02019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11510-4https://doaj.org/toc/2041-1723Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regulator C/EBPβ.Tânia D. F. CostaTing ZhuangJulie LorentEmilia TurcoHelene OlofssonMiriam Masia-BalagueMiao ZhaoParisa RabieifarNeil RobertsonRaoul KuiperJonas SjölundMatthias SpiessPablo Hernández-VarasUta RabenhorstPernilla RoswallRan MaXiaowei GongJohan HartmanKristian PietrasPeter D. AdamsPaola DefilippiStaffan StrömbladNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-18 (2019) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tânia D. F. Costa Ting Zhuang Julie Lorent Emilia Turco Helene Olofsson Miriam Masia-Balague Miao Zhao Parisa Rabieifar Neil Robertson Raoul Kuiper Jonas Sjölund Matthias Spiess Pablo Hernández-Varas Uta Rabenhorst Pernilla Roswall Ran Ma Xiaowei Gong Johan Hartman Kristian Pietras Peter D. Adams Paola Defilippi Staffan Strömblad PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| description |
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regulator C/EBPβ. |
| format |
article |
| author |
Tânia D. F. Costa Ting Zhuang Julie Lorent Emilia Turco Helene Olofsson Miriam Masia-Balague Miao Zhao Parisa Rabieifar Neil Robertson Raoul Kuiper Jonas Sjölund Matthias Spiess Pablo Hernández-Varas Uta Rabenhorst Pernilla Roswall Ran Ma Xiaowei Gong Johan Hartman Kristian Pietras Peter D. Adams Paola Defilippi Staffan Strömblad |
| author_facet |
Tânia D. F. Costa Ting Zhuang Julie Lorent Emilia Turco Helene Olofsson Miriam Masia-Balague Miao Zhao Parisa Rabieifar Neil Robertson Raoul Kuiper Jonas Sjölund Matthias Spiess Pablo Hernández-Varas Uta Rabenhorst Pernilla Roswall Ran Ma Xiaowei Gong Johan Hartman Kristian Pietras Peter D. Adams Paola Defilippi Staffan Strömblad |
| author_sort |
Tânia D. F. Costa |
| title |
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| title_short |
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| title_full |
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| title_fullStr |
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| title_full_unstemmed |
PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer |
| title_sort |
pak4 suppresses relb to prevent senescence-like growth arrest in breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0 |
| work_keys_str_mv |
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