PAK4 suppresses RELB to prevent senescence-like growth arrest in breast cancer
Oncogene induced senescence protects cells from unrestricted growth and cancer. Here, the authors show that PAK4 overrides this senescence in breast cancer cells through phosphorylation of RELB, thereby inhibiting transcription of the senescence regulator C/EBPβ.
Guardado en:
Autores principales: | Tânia D. F. Costa, Ting Zhuang, Julie Lorent, Emilia Turco, Helene Olofsson, Miriam Masia-Balague, Miao Zhao, Parisa Rabieifar, Neil Robertson, Raoul Kuiper, Jonas Sjölund, Matthias Spiess, Pablo Hernández-Varas, Uta Rabenhorst, Pernilla Roswall, Ran Ma, Xiaowei Gong, Johan Hartman, Kristian Pietras, Peter D. Adams, Paola Defilippi, Staffan Strömblad |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2019
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b1b8d976c5c54a27ab395cced065f0c0 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Pdx1-Cre-driven conditional gene depletion suggests PAK4 as dispensable for mouse pancreas development
por: Miao Zhao, et al.
Publicado: (2017) -
Characterization of the interaction and cross-regulation of three Mycobacterium tuberculosis RelBE modules.
por: Min Yang, et al.
Publicado: (2010) -
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
por: Guilhem Lalle, et al.
Publicado: (2021) -
Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins
por: Alice C. Newman, et al.
Publicado: (2017) -
Pak1 kinase controls cell shape through ribonucleoprotein granules
por: Joseph O Magliozzi, et al.
Publicado: (2021)