Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study.
<h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided mate...
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Public Library of Science (PLoS)
2013
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oai:doaj.org-article:b1b93d1cb3d947ebbb629518b6cb65072021-11-18T08:46:44ZAssociation of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study.1932-620310.1371/journal.pone.0079803https://doaj.org/article/b1b93d1cb3d947ebbb629518b6cb65072013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24236160/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status.<h4>Findings</h4>We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)).<h4>Conclusion</h4>The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.Kelly MorganMohammed RahmanMark AtkinsonShang-Ming ZhouRebecca HillAshrafunnesa KhanomShantini ParanjothySinead BrophyPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79803 (2013) |
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Medicine R Science Q |
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Medicine R Science Q Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| description |
<h4>Background</h4>This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years.<h4>Methods</h4>A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status.<h4>Findings</h4>We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)).<h4>Conclusion</h4>The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'. |
| format |
article |
| author |
Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy |
| author_facet |
Kelly Morgan Mohammed Rahman Mark Atkinson Shang-Ming Zhou Rebecca Hill Ashrafunnesa Khanom Shantini Paranjothy Sinead Brophy |
| author_sort |
Kelly Morgan |
| title |
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_short |
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_full |
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_fullStr |
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_full_unstemmed |
Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| title_sort |
association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/b1b93d1cb3d947ebbb629518b6cb6507 |
| work_keys_str_mv |
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