Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis

Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness...

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Autores principales:	Lavanya Cherukuri, Divya Birudaraju, Matthew J Budoff
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/b1ba96ed4af5457da19b01d480e49e9c
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spelling	oai:doaj.org-article:b1ba96ed4af5457da19b01d480e49e9c2021-12-04T16:04:20ZNovel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis10.15420/usc.2020.241758-390X1758-3896https://doaj.org/article/b1ba96ed4af5457da19b01d480e49e9c2021-04-01T00:00:00Zhttps://www.uscjournal.com/articleindex/usc.2020.24https://doaj.org/toc/1758-3896https://doaj.org/toc/1758-390XCoronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFRCT) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFRCT has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques.Lavanya CherukuriDivya BirudarajuMatthew J BudoffRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENUS Cardiology Review , Vol 15, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Lavanya Cherukuri Divya Birudaraju Matthew J Budoff Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
description	Coronary artery disease (CAD) patients may have an obstructive disease on invasive coronary angiography, but few of these patients have had flow-limiting obstructive disease diagnosed on invasive fractional flow reserve (FFR). FFR is infrequently performed because of its cost- and time-effectiveness. Advancement in non-invasive imaging has enabled FFR to be derived non-invasively using coronary CT angiography (CCTA), without the need for induction of hyperemia or modification of the standard CCTA acquisition protocol. FFR derived from CCTA (FFRCT) has been shown to have excellent correlation with invasive FFR, and remains an effective diagnostic tool in the presence of reduced signal-to-noise ratio, coronary calcification and motion artifact. The utility of FFRCT has also helped to deepen our understanding of hemodynamically significant CAD. Hence, there is now interest in exploring the possible interplay between these mechanistic forces and their effect on the development of coronary plaque and the vulnerability of these plaques.
format	article
author	Lavanya Cherukuri Divya Birudaraju Matthew J Budoff
author_facet	Lavanya Cherukuri Divya Birudaraju Matthew J Budoff
author_sort	Lavanya Cherukuri
title	Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
title_short	Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
title_full	Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
title_fullStr	Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
title_full_unstemmed	Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis
title_sort	novel non-invasive fractional flow reserve from coronary ct angiography to determine ischemic coronary stenosis
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/b1ba96ed4af5457da19b01d480e49e9c
work_keys_str_mv	AT lavanyacherukuri novelnoninvasivefractionalflowreservefromcoronaryctangiographytodetermineischemiccoronarystenosis AT divyabirudaraju novelnoninvasivefractionalflowreservefromcoronaryctangiographytodetermineischemiccoronarystenosis AT matthewjbudoff novelnoninvasivefractionalflowreservefromcoronaryctangiographytodetermineischemiccoronarystenosis
_version_	1718372695706435584

Novel Non-invasive Fractional Flow Reserve from Coronary CT Angiography to Determine Ischemic Coronary Stenosis

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