Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography

Abstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (...

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Autores principales:	Nathalie Massamba, Anna G. Mackin, Lindsay Y. Chun, Sarah Rodriguez, Rose C. Dimitroyannis, Bahram Bodaghi, Seenu M. Hariprasad, Dimitra Skondra
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1bc4d0b885a4b5598816a77b0f8c5a6
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spelling	oai:doaj.org-article:b1bc4d0b885a4b5598816a77b0f8c5a62021-11-14T12:21:28ZEvaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography10.1038/s41598-021-01380-62045-2322https://doaj.org/article/b1bc4d0b885a4b5598816a77b0f8c5a62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01380-6https://doaj.org/toc/2045-2322Abstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases.Nathalie MassambaAnna G. MackinLindsay Y. ChunSarah RodriguezRose C. DimitroyannisBahram BodaghiSeenu M. HariprasadDimitra SkondraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
description	Abstract This study compared macular capillary parameters between healthy black and white subjects using optical coherence tomography angiography (OCTA). We measured vessel density (VD) of superficial (SCP), intermediate (ICP), and deep (DCP) capillary plexuses and choriocapillaris blood flow area (BFA) of the fovea, parafovea and total 3 mm-diameter circular area centered on the fovea, as well as the foveal avascular zone (FAZ) parameters, controlling for axial length. Black subjects had lower foveal and parafoveal VD in the SCP (p = 0.043 and p = 0.014) and the ICP (p = 0.014 and p = 0.002). In the DCP, black subjects had a trend toward lower foveal and parafoveal VD. Black subjects had decreased choriocapillaris BFA in the total 3 mm area (p = 0.011) and the parafovea (p = 0.033), larger FAZ area (p = 0.006) and perimeter (p = 0.014), and a higher capillary density in a 300 μm wide region around the FAZ (FD-300) (p = 0.001). There was no significant difference in FAZ acircularity index. To our knowledge, this is the first report analyzing the three distinct retinal capillary plexuses and identifying differing baseline VD, choriocapillaris and FAZ parameters in healthy young black compared to white subjects. Larger studies are needed to validate these findings and better understand racial differences in vulnerability to ocular diseases.
format	article
author	Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra
author_facet	Nathalie Massamba Anna G. Mackin Lindsay Y. Chun Sarah Rodriguez Rose C. Dimitroyannis Bahram Bodaghi Seenu M. Hariprasad Dimitra Skondra
author_sort	Nathalie Massamba
title	Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
title_short	Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
title_full	Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
title_fullStr	Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
title_full_unstemmed	Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
title_sort	evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1bc4d0b885a4b5598816a77b0f8c5a6
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Evaluation of flow of chorioretinal capillaries in healthy black and white subjects using optical coherence tomography angiography

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