Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in develo...

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Autores principales:	Michael J. Petrany, Casey O. Swoboda, Chengyi Sun, Kashish Chetal, Xiaoting Chen, Matthew T. Weirauch, Nathan Salomonis, Douglas P. Millay
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
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spelling	oai:doaj.org-article:b1bd009b492847ec94ecd25cf3c44bce2021-12-02T14:16:05ZSingle-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers10.1038/s41467-020-20063-w2041-1723https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20063-whttps://doaj.org/toc/2041-1723Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.Michael J. PetranyCasey O. SwobodaChengyi SunKashish ChetalXiaoting ChenMatthew T. WeirauchNathan SalomonisDouglas P. MillayNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael J. Petrany Casey O. Swoboda Chengyi Sun Kashish Chetal Xiaoting Chen Matthew T. Weirauch Nathan Salomonis Douglas P. Millay Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
description	Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in development and aging.
format	article
author	Michael J. Petrany Casey O. Swoboda Chengyi Sun Kashish Chetal Xiaoting Chen Matthew T. Weirauch Nathan Salomonis Douglas P. Millay
author_facet	Michael J. Petrany Casey O. Swoboda Chengyi Sun Kashish Chetal Xiaoting Chen Matthew T. Weirauch Nathan Salomonis Douglas P. Millay
author_sort	Michael J. Petrany
title	Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
title_short	Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
title_full	Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
title_fullStr	Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
title_full_unstemmed	Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
title_sort	single-nucleus rna-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
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Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

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