Single-nucleus RNA-seq identifies transcriptional heterogeneity in multinucleated skeletal myofibers

Mammalian skeletal muscle is composed of multinucleated myofibers, containing hundreds of nuclei that coordinate cellular function. Here, the authors show that single-nucleus RNA-sequencing reveals rare and emergent myonuclear populations, and uncovers dynamic transcriptional heterogeneity in develo...

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Bibliographic Details
Main Authors: Michael J. Petrany, Casey O. Swoboda, Chengyi Sun, Kashish Chetal, Xiaoting Chen, Matthew T. Weirauch, Nathan Salomonis, Douglas P. Millay
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/b1bd009b492847ec94ecd25cf3c44bce
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