DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

Granulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group of children and adolescents with latent TB in...

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Autores principales:	M. M. (Jr) Averbakh, L. V. Panova, M. F. Gubkina, N. I. Evseeva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	tuberculosis children adolescent innate immunity granulysin cathelicidin Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b1c1045c21824412a67690f0d6a43fac
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spelling	oai:doaj.org-article:b1c1045c21824412a67690f0d6a43fac2021-11-18T08:03:47ZDYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS1563-06252313-741X10.15789/1563-0625-2018-5-747-752https://doaj.org/article/b1c1045c21824412a67690f0d6a43fac2018-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1643https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XGranulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group of children and adolescents with latent TB infection. Patients with tuberculosis of the respiratory system exhibit significantly lower amounts of serum cathelicidin in destructive forms, as well as granulysin levels in “minor” forms of tuberculosis before starting the specific chemotherapy. The chemotherapy performed did not influence the serum granulysin and cathelicidin contents in patients with destructive tuberculosis, whereas the patients with “minor” forms (TLN/focal tuberculosis) revealed a significant increase in granulysin content after 6 months of treatment, and same trend for cathelicidin concentrations after 3 months of chemotherapy, followed by subsequent return to baseline values.M. M. (Jr) AverbakhL. V. PanovaM. F. GubkinaN. I. EvseevaSPb RAACIarticletuberculosischildrenadolescentinnate immunitygranulysincathelicidinImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 5, Pp 747-752 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	tuberculosis children adolescent innate immunity granulysin cathelicidin Immunologic diseases. Allergy RC581-607
spellingShingle	tuberculosis children adolescent innate immunity granulysin cathelicidin Immunologic diseases. Allergy RC581-607 M. M. (Jr) Averbakh L. V. Panova M. F. Gubkina N. I. Evseeva DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
description	Granulysin and cathelicidin, the cytolytic molecules of innate immune system are important protective factors during infection with Mycobacterium tuberculosis. We present original data concerning high levels of granulysin and cathelicidin among the group of children and adolescents with latent TB infection. Patients with tuberculosis of the respiratory system exhibit significantly lower amounts of serum cathelicidin in destructive forms, as well as granulysin levels in “minor” forms of tuberculosis before starting the specific chemotherapy. The chemotherapy performed did not influence the serum granulysin and cathelicidin contents in patients with destructive tuberculosis, whereas the patients with “minor” forms (TLN/focal tuberculosis) revealed a significant increase in granulysin content after 6 months of treatment, and same trend for cathelicidin concentrations after 3 months of chemotherapy, followed by subsequent return to baseline values.
format	article
author	M. M. (Jr) Averbakh L. V. Panova M. F. Gubkina N. I. Evseeva
author_facet	M. M. (Jr) Averbakh L. V. Panova M. F. Gubkina N. I. Evseeva
author_sort	M. M. (Jr) Averbakh
title	DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_short	DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_full	DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_fullStr	DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_full_unstemmed	DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS
title_sort	dynamic changes of granulysin and cathelicidin in children and adolescents with different forms of pulmonary tuberculosis
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/b1c1045c21824412a67690f0d6a43fac
work_keys_str_mv	AT mmjraverbakh dynamicchangesofgranulysinandcathelicidininchildrenandadolescentswithdifferentformsofpulmonarytuberculosis AT lvpanova dynamicchangesofgranulysinandcathelicidininchildrenandadolescentswithdifferentformsofpulmonarytuberculosis AT mfgubkina dynamicchangesofgranulysinandcathelicidininchildrenandadolescentswithdifferentformsofpulmonarytuberculosis AT nievseeva dynamicchangesofgranulysinandcathelicidininchildrenandadolescentswithdifferentformsofpulmonarytuberculosis
_version_	1718422373375410176

DYNAMIC CHANGES OF GRANULYSIN AND CATHELICIDIN IN CHILDREN AND ADOLESCENTS WITH DIFFERENT FORMS OF PULMONARY TUBERCULOSIS

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