A critical view on transgenerational epigenetic inheritance in humans
Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the s...
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2018
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oai:doaj.org-article:b1c1be1cf2004d32baf2eaa2802727242021-12-02T16:56:56ZA critical view on transgenerational epigenetic inheritance in humans10.1038/s41467-018-05445-52041-1723https://doaj.org/article/b1c1be1cf2004d32baf2eaa2802727242018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05445-5https://doaj.org/toc/2041-1723Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.Bernhard HorsthemkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-4 (2018) |
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Science Q Bernhard Horsthemke A critical view on transgenerational epigenetic inheritance in humans |
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Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies. |
| format |
article |
| author |
Bernhard Horsthemke |
| author_facet |
Bernhard Horsthemke |
| author_sort |
Bernhard Horsthemke |
| title |
A critical view on transgenerational epigenetic inheritance in humans |
| title_short |
A critical view on transgenerational epigenetic inheritance in humans |
| title_full |
A critical view on transgenerational epigenetic inheritance in humans |
| title_fullStr |
A critical view on transgenerational epigenetic inheritance in humans |
| title_full_unstemmed |
A critical view on transgenerational epigenetic inheritance in humans |
| title_sort |
critical view on transgenerational epigenetic inheritance in humans |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/b1c1be1cf2004d32baf2eaa280272724 |
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AT bernhardhorsthemke acriticalviewontransgenerationalepigeneticinheritanceinhumans AT bernhardhorsthemke criticalviewontransgenerationalepigeneticinheritanceinhumans |
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1718382700466798592 |