A critical view on transgenerational epigenetic inheritance in humans

Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the s...

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Autor principal:	Bernhard Horsthemke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1c1be1cf2004d32baf2eaa280272724
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spelling	oai:doaj.org-article:b1c1be1cf2004d32baf2eaa2802727242021-12-02T16:56:56ZA critical view on transgenerational epigenetic inheritance in humans10.1038/s41467-018-05445-52041-1723https://doaj.org/article/b1c1be1cf2004d32baf2eaa2802727242018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05445-5https://doaj.org/toc/2041-1723Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.Bernhard HorsthemkeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-4 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernhard Horsthemke A critical view on transgenerational epigenetic inheritance in humans
description	Abstract Transgenerational epigenetic inheritance refers to the transmission of epigenetic information through the germline. While it has been observed in plants, nematodes and fruit flies, its occurrence in mammals—and humans in particular—is the matter of controversial debate, mostly because the study of transgenerational epigenetic inheritance is confounded by genetic, ecological and cultural inheritance. In this comment, I discuss the phenomenon of transgenerational epigenetic inheritance and the difficulty of providing conclusive proof for it in experimental and observational studies.
format	article
author	Bernhard Horsthemke
author_facet	Bernhard Horsthemke
author_sort	Bernhard Horsthemke
title	A critical view on transgenerational epigenetic inheritance in humans
title_short	A critical view on transgenerational epigenetic inheritance in humans
title_full	A critical view on transgenerational epigenetic inheritance in humans
title_fullStr	A critical view on transgenerational epigenetic inheritance in humans
title_full_unstemmed	A critical view on transgenerational epigenetic inheritance in humans
title_sort	critical view on transgenerational epigenetic inheritance in humans
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b1c1be1cf2004d32baf2eaa280272724
work_keys_str_mv	AT bernhardhorsthemke acriticalviewontransgenerationalepigeneticinheritanceinhumans AT bernhardhorsthemke criticalviewontransgenerationalepigeneticinheritanceinhumans
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A critical view on transgenerational epigenetic inheritance in humans

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