Dysbiosis and Its Discontents

ABSTRACT Dysbiosis is a key term in human microbiome research, especially when microbiome patterns are associated with disease states. Although some questions have been raised about how this term is applied, its use continues undiminished in the literature. We investigate the ways in which microbiom...

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Autores principales:	Katarzyna B. Hooks, Maureen A. O’Malley
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	dysbiosis homeostasis microbial diversity microbiome microbiota Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b1c3f16caf744b78b122b14d5f2993c9
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id	oai:doaj.org-article:b1c3f16caf744b78b122b14d5f2993c9
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spelling	oai:doaj.org-article:b1c3f16caf744b78b122b14d5f2993c92021-11-15T15:51:51ZDysbiosis and Its Discontents10.1128/mBio.01492-172150-7511https://doaj.org/article/b1c3f16caf744b78b122b14d5f2993c92017-11-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01492-17https://doaj.org/toc/2150-7511ABSTRACT Dysbiosis is a key term in human microbiome research, especially when microbiome patterns are associated with disease states. Although some questions have been raised about how this term is applied, its use continues undiminished in the literature. We investigate the ways in which microbiome researchers discuss dysbiosis and then assess the impact of different concepts of dysbiosis on microbiome research. After an overview of the term’s historical roots, we conduct quantitative and qualitative analyses of a large selection of contemporary dysbiosis statements. We categorize both short definitions and longer conceptual statements about dysbiosis. Further analysis allows us to identify the problematic implications of how dysbiosis is used, particularly with regard to causal hypotheses and normal-abnormal distinctions. We suggest that researchers should reflect carefully on the ways in which they discuss dysbiosis, in order for the field to continue to develop greater predictive scope and explanatory depth.Katarzyna B. HooksMaureen A. O’MalleyAmerican Society for Microbiologyarticledysbiosishomeostasismicrobial diversitymicrobiomemicrobiotaMicrobiologyQR1-502ENmBio, Vol 8, Iss 5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	dysbiosis homeostasis microbial diversity microbiome microbiota Microbiology QR1-502
spellingShingle	dysbiosis homeostasis microbial diversity microbiome microbiota Microbiology QR1-502 Katarzyna B. Hooks Maureen A. O’Malley Dysbiosis and Its Discontents
description	ABSTRACT Dysbiosis is a key term in human microbiome research, especially when microbiome patterns are associated with disease states. Although some questions have been raised about how this term is applied, its use continues undiminished in the literature. We investigate the ways in which microbiome researchers discuss dysbiosis and then assess the impact of different concepts of dysbiosis on microbiome research. After an overview of the term’s historical roots, we conduct quantitative and qualitative analyses of a large selection of contemporary dysbiosis statements. We categorize both short definitions and longer conceptual statements about dysbiosis. Further analysis allows us to identify the problematic implications of how dysbiosis is used, particularly with regard to causal hypotheses and normal-abnormal distinctions. We suggest that researchers should reflect carefully on the ways in which they discuss dysbiosis, in order for the field to continue to develop greater predictive scope and explanatory depth.
format	article
author	Katarzyna B. Hooks Maureen A. O’Malley
author_facet	Katarzyna B. Hooks Maureen A. O’Malley
author_sort	Katarzyna B. Hooks
title	Dysbiosis and Its Discontents
title_short	Dysbiosis and Its Discontents
title_full	Dysbiosis and Its Discontents
title_fullStr	Dysbiosis and Its Discontents
title_full_unstemmed	Dysbiosis and Its Discontents
title_sort	dysbiosis and its discontents
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/b1c3f16caf744b78b122b14d5f2993c9
work_keys_str_mv	AT katarzynabhooks dysbiosisanditsdiscontents AT maureenaomalley dysbiosisanditsdiscontents
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Dysbiosis and Its Discontents

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