Oligodendrocyte Development and Implication in Perinatal White Matter Injury

Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of...

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Autores principales:	Mahsa Motavaf, Xianhua Piao
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	white matter injury oligodendrocyte premature birth hypoxia-ischemia myelin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/b1c4497827e44ea7bae0a2fd9e8d04f7
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spelling	oai:doaj.org-article:b1c4497827e44ea7bae0a2fd9e8d04f72021-11-04T05:53:27ZOligodendrocyte Development and Implication in Perinatal White Matter Injury1662-510210.3389/fncel.2021.764486https://doaj.org/article/b1c4497827e44ea7bae0a2fd9e8d04f72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.764486/fullhttps://doaj.org/toc/1662-5102Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets.Mahsa MotavafXianhua PiaoXianhua PiaoXianhua PiaoXianhua PiaoFrontiers Media S.A.articlewhite matter injuryoligodendrocytepremature birthhypoxia-ischemiamyelinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	white matter injury oligodendrocyte premature birth hypoxia-ischemia myelin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	white matter injury oligodendrocyte premature birth hypoxia-ischemia myelin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Mahsa Motavaf Xianhua Piao Xianhua Piao Xianhua Piao Xianhua Piao Oligodendrocyte Development and Implication in Perinatal White Matter Injury
description	Perinatal white matter injury (WMI) is the most common brain injury in premature infants and can lead to life-long neurological deficits such as cerebral palsy. Preterm birth is typically accompanied by inflammation and hypoxic-ischemic events. Such perinatal insults negatively impact maturation of oligodendrocytes (OLs) and cause myelination failure. At present, no treatment options are clinically available to prevent or cure WMI. Given that arrested OL maturation plays a central role in the etiology of perinatal WMI, an increased interest has emerged regarding the functional restoration of these cells as potential therapeutic strategy. Cell transplantation and promoting endogenous oligodendrocyte function are two potential options to address this major unmet need. In this review, we highlight the underlying pathophysiology of WMI with a specific focus on OL biology and their implication for the development of new therapeutic targets.
format	article
author	Mahsa Motavaf Xianhua Piao Xianhua Piao Xianhua Piao Xianhua Piao
author_facet	Mahsa Motavaf Xianhua Piao Xianhua Piao Xianhua Piao Xianhua Piao
author_sort	Mahsa Motavaf
title	Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_short	Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_full	Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_fullStr	Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_full_unstemmed	Oligodendrocyte Development and Implication in Perinatal White Matter Injury
title_sort	oligodendrocyte development and implication in perinatal white matter injury
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b1c4497827e44ea7bae0a2fd9e8d04f7
work_keys_str_mv	AT mahsamotavaf oligodendrocytedevelopmentandimplicationinperinatalwhitematterinjury AT xianhuapiao oligodendrocytedevelopmentandimplicationinperinatalwhitematterinjury AT xianhuapiao oligodendrocytedevelopmentandimplicationinperinatalwhitematterinjury AT xianhuapiao oligodendrocytedevelopmentandimplicationinperinatalwhitematterinjury AT xianhuapiao oligodendrocytedevelopmentandimplicationinperinatalwhitematterinjury
_version_	1718445234938970112

Oligodendrocyte Development and Implication in Perinatal White Matter Injury

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