Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

HLA alleles and microbiome alterations have been separately associated with human autoimmunity. Here the authors identify differences in stool microbiome between healthy carriers of HLA alleles conferring low- and high-risk for type 1 diabetes, suggesting that HLA shaping of microbiome may contribut...

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Autores principales:	Jordan T. Russell, Luiz F. W. Roesch, Malin Ördberg, Jorma Ilonen, Mark A. Atkinson, Desmond A. Schatz, Eric W. Triplett, Johnny Ludvigsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1c5abc6f37a4cff909ed60a09d13270
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spelling	oai:doaj.org-article:b1c5abc6f37a4cff909ed60a09d132702021-12-02T16:58:13ZGenetic risk for autoimmunity is associated with distinct changes in the human gut microbiome10.1038/s41467-019-11460-x2041-1723https://doaj.org/article/b1c5abc6f37a4cff909ed60a09d132702019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11460-xhttps://doaj.org/toc/2041-1723HLA alleles and microbiome alterations have been separately associated with human autoimmunity. Here the authors identify differences in stool microbiome between healthy carriers of HLA alleles conferring low- and high-risk for type 1 diabetes, suggesting that HLA shaping of microbiome may contribute to HLA impact on autoimmunity risks.Jordan T. RussellLuiz F. W. RoeschMalin ÖrdbergJorma IlonenMark A. AtkinsonDesmond A. SchatzEric W. TriplettJohnny LudvigssonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordan T. Russell Luiz F. W. Roesch Malin Ördberg Jorma Ilonen Mark A. Atkinson Desmond A. Schatz Eric W. Triplett Johnny Ludvigsson Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
description	HLA alleles and microbiome alterations have been separately associated with human autoimmunity. Here the authors identify differences in stool microbiome between healthy carriers of HLA alleles conferring low- and high-risk for type 1 diabetes, suggesting that HLA shaping of microbiome may contribute to HLA impact on autoimmunity risks.
format	article
author	Jordan T. Russell Luiz F. W. Roesch Malin Ördberg Jorma Ilonen Mark A. Atkinson Desmond A. Schatz Eric W. Triplett Johnny Ludvigsson
author_facet	Jordan T. Russell Luiz F. W. Roesch Malin Ördberg Jorma Ilonen Mark A. Atkinson Desmond A. Schatz Eric W. Triplett Johnny Ludvigsson
author_sort	Jordan T. Russell
title	Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
title_short	Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
title_full	Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
title_fullStr	Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
title_full_unstemmed	Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
title_sort	genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b1c5abc6f37a4cff909ed60a09d13270
work_keys_str_mv	AT jordantrussell geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT luizfwroesch geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT malinordberg geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT jormailonen geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT markaatkinson geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT desmondaschatz geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT ericwtriplett geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome AT johnnyludvigsson geneticriskforautoimmunityisassociatedwithdistinctchangesinthehumangutmicrobiome
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Genetic risk for autoimmunity is associated with distinct changes in the human gut microbiome

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