Measurement of lipogenic flux by deuterium resolved mass spectrometry

Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice following a brief and low dose of deuterated water.

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Autores principales:	Xiaorong Fu, Stanisław Deja, Justin A. Fletcher, Norma N. Anderson, Monika Mizerska, Gonçalo Vale, Jeffrey D. Browning, Jay D. Horton, Jeffrey G. McDonald, Matthew A. Mitsche, Shawn C. Burgess
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
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spelling	oai:doaj.org-article:b1cab25a3bac4392a10db218cc30d3232021-12-02T17:24:09ZMeasurement of lipogenic flux by deuterium resolved mass spectrometry10.1038/s41467-021-23958-42041-1723https://doaj.org/article/b1cab25a3bac4392a10db218cc30d3232021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23958-4https://doaj.org/toc/2041-1723Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice following a brief and low dose of deuterated water.Xiaorong FuStanisław DejaJustin A. FletcherNorma N. AndersonMonika MizerskaGonçalo ValeJeffrey D. BrowningJay D. HortonJeffrey G. McDonaldMatthew A. MitscheShawn C. BurgessNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaorong Fu Stanisław Deja Justin A. Fletcher Norma N. Anderson Monika Mizerska Gonçalo Vale Jeffrey D. Browning Jay D. Horton Jeffrey G. McDonald Matthew A. Mitsche Shawn C. Burgess Measurement of lipogenic flux by deuterium resolved mass spectrometry
description	Fat synthesis is necessary for normal physiology, but its dysregulation contributes to the pathology of many diseases. Here, the authors report a high-resolution mass spectrometry approach that quantifies fat synthesis flux in humans and mice following a brief and low dose of deuterated water.
format	article
author	Xiaorong Fu Stanisław Deja Justin A. Fletcher Norma N. Anderson Monika Mizerska Gonçalo Vale Jeffrey D. Browning Jay D. Horton Jeffrey G. McDonald Matthew A. Mitsche Shawn C. Burgess
author_facet	Xiaorong Fu Stanisław Deja Justin A. Fletcher Norma N. Anderson Monika Mizerska Gonçalo Vale Jeffrey D. Browning Jay D. Horton Jeffrey G. McDonald Matthew A. Mitsche Shawn C. Burgess
author_sort	Xiaorong Fu
title	Measurement of lipogenic flux by deuterium resolved mass spectrometry
title_short	Measurement of lipogenic flux by deuterium resolved mass spectrometry
title_full	Measurement of lipogenic flux by deuterium resolved mass spectrometry
title_fullStr	Measurement of lipogenic flux by deuterium resolved mass spectrometry
title_full_unstemmed	Measurement of lipogenic flux by deuterium resolved mass spectrometry
title_sort	measurement of lipogenic flux by deuterium resolved mass spectrometry
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1cab25a3bac4392a10db218cc30d323
work_keys_str_mv	AT xiaorongfu measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT stanisławdeja measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT justinafletcher measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT normananderson measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT monikamizerska measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT goncalovale measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT jeffreydbrowning measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT jaydhorton measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT jeffreygmcdonald measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT matthewamitsche measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry AT shawncburgess measurementoflipogenicfluxbydeuteriumresolvedmassspectrometry
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Measurement of lipogenic flux by deuterium resolved mass spectrometry

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