Engineered HSV vector achieves safe long-term transgene expression in the central nervous system

Abstract Previously we reported a new series of highly defective herpes simplex virus type 1 (HSV-1) vectors that were functionally devoid of all viral immediately early (IE) genes, resulting in virtual absence of viral gene expression. Nevertheless, a reporter gene cassette inserted into the vector...

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Autores principales: Gianluca Verlengia, Yoshitaka Miyagawa, Selene Ingusci, Justus B. Cohen, Michele Simonato, Joseph C. Glorioso
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/b1d3758c4d1a4cf094352f0ec281ebd2
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