CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION

Abstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cor...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	I. A. Botvin’eva, L. V. Renge, V. N. Zorina, R. M. Zorina, A. N. Polukarov, L. G. Bazhenova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	chlamydia trachomatis igg antibodies pregnancy polyhydramnion intrauterine infection cytokines Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b1d6e4d4d0ba4d3dbc13dfddea95a99f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b1d6e4d4d0ba4d3dbc13dfddea95a99f
record_format	dspace
spelling	oai:doaj.org-article:b1d6e4d4d0ba4d3dbc13dfddea95a99f2021-11-18T08:03:43ZCYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION1563-06252313-741X10.15789/1563-0625-2013-3-277-282https://doaj.org/article/b1d6e4d4d0ba4d3dbc13dfddea95a99f2014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/602https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cord blood sera, obtained at delivery. We had found high levels of TNFα, IL-6, IL-8, IL-10 in sera from umbilical cord blood, and increased levels of TNFα in maternal sera before delivery in a group of women with high Apgar scores of their children (≥ 8 points), in comparison with control group. High levels of TNFα, IL-6, IL-10 in sera from umbical cord and increased serum concentrations of IL-6, IL-10, IL-1ra and TNFα before delivery were evaluated in group of women with circulating antibodies against C. trachomatis during pregnancy and with low degrees of newborn children (< 7 by Apgar score). We suggest that high cytokine levels in maternal blood and in sera of umbilical cord blood from women with polyhydramnios and circulating antibodies against C. trachomatis sufficiently correlate with high clinical risk of intrauterine infection in newborns. However, high inter-individual variability of the cytokine parameters does not permit their usage as independent diagnostic criteria.I. A. Botvin’evaL. V. RengeV. N. ZorinaR. M. ZorinaA. N. PolukarovL. G. BazhenovaSPb RAACIarticlechlamydia trachomatisigg antibodiespregnancypolyhydramnionintrauterine infectioncytokinesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 3, Pp 277-282 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	chlamydia trachomatis igg antibodies pregnancy polyhydramnion intrauterine infection cytokines Immunologic diseases. Allergy RC581-607
spellingShingle	chlamydia trachomatis igg antibodies pregnancy polyhydramnion intrauterine infection cytokines Immunologic diseases. Allergy RC581-607 I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
description	Abstract. We had investigated serum levels of IL-6, IL-8, IL-10, IL-1ra and TNFα in peripheral blood of pregnant women at the terms of 38 to 40 weeks with polyhydramnios and serum IgG antibodies specific for Chlamydia trachomatis (titers of 1:20 to 1:40). Same parameters were tested in umbilical cord blood sera, obtained at delivery. We had found high levels of TNFα, IL-6, IL-8, IL-10 in sera from umbilical cord blood, and increased levels of TNFα in maternal sera before delivery in a group of women with high Apgar scores of their children (≥ 8 points), in comparison with control group. High levels of TNFα, IL-6, IL-10 in sera from umbical cord and increased serum concentrations of IL-6, IL-10, IL-1ra and TNFα before delivery were evaluated in group of women with circulating antibodies against C. trachomatis during pregnancy and with low degrees of newborn children (< 7 by Apgar score). We suggest that high cytokine levels in maternal blood and in sera of umbilical cord blood from women with polyhydramnios and circulating antibodies against C. trachomatis sufficiently correlate with high clinical risk of intrauterine infection in newborns. However, high inter-individual variability of the cytokine parameters does not permit their usage as independent diagnostic criteria.
format	article
author	I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova
author_facet	I. A. Botvin’eva L. V. Renge V. N. Zorina R. M. Zorina A. N. Polukarov L. G. Bazhenova
author_sort	I. A. Botvin’eva
title	CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
title_short	CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
title_full	CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
title_fullStr	CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
title_full_unstemmed	CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION
title_sort	cytokine levels in maternal blood and umbical cord sera from women with symptoms of intrauterine infection
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b1d6e4d4d0ba4d3dbc13dfddea95a99f
work_keys_str_mv	AT iabotvineva cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection AT lvrenge cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection AT vnzorina cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection AT rmzorina cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection AT anpolukarov cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection AT lgbazhenova cytokinelevelsinmaternalbloodandumbicalcordserafromwomenwithsymptomsofintrauterineinfection
_version_	1718422441642950656

CYTOKINE LEVELS IN MATERNAL BLOOD AND UMBICAL CORD SERA FROM WOMEN WITH SYMPTOMS OF INTRAUTERINE INFECTION

Ejemplares similares