Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19

Objective: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. Design: An observational, analytical, retrospective cohort study with longitudinal follow-up. Setting: Hospital Universitario Príncipe de As...

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Autores principales:	Jorge Monserrat, Angel Asunsolo, Ana Gómez-Lahoz, Miguel A. Ortega, Jose Maria Gasalla, Óscar Gasulla, Jordi Fortuny-Profitós, Ferran A. Mazaira-Font, Miguel Teixidó Román, Alberto Arranz, José Sanz, Benjamin Muñoz, Juan Arévalo-Serrano, José Miguel Rodríguez, Carlos Martínez-A, Dimitri Balomenos, Melchor Álvarez-Mon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	SARS-CoV-2 ICU innate inflammatory response COVID-19 cytokines Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b1d72c62152a471b83fc33cb7348db60
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spelling	oai:doaj.org-article:b1d72c62152a471b83fc33cb7348db602021-11-25T16:50:41ZImpact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-1910.3390/biomedicines91116752227-9059https://doaj.org/article/b1d72c62152a471b83fc33cb7348db602021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1675https://doaj.org/toc/2227-9059Objective: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. Design: An observational, analytical, retrospective cohort study with longitudinal follow-up. Setting: Hospital Universitario Príncipe de Asturias (HUPA). Participants: 287 patients diagnosed with COVID-19 admitted to our hospital from 24 March to 8 May 2020, followed until 31 August 2020. Main outcome measures: Profiles of immune response (IR) mediators were determined using the Luminex Multiplex technique in hospitalized patients within six days of admission by examining serum levels of 62 soluble molecules classified into the three groups: adaptive IR-related cytokines (<i>n</i> = 19), innate inflammatory IR-related cytokines (<i>n</i> = 27), and growth factors (<i>n</i> = 16). Results: A statistically robust link with ICU admission and/or death was detected for increased serum levels of interleukin (IL)-6, IL-15, soluble (s) RAGE, IP10, MCP3, sIL1RII, IL-8, GCSF and MCSF and IL-10. The greatest prognostic value was observed for the marker combination IL-10, IL-6 and GCSF. Conclusions: When severe COVID-19 progresses to ICU admission and/or death there is a marked increase in serum levels of several cytokines and chemokines, mainly related to the patient’s inflammatory IR. Serum levels of IL-10, IL-6 and GCSF were most prognostic of the outcome measure.Jorge MonserratAngel AsunsoloAna Gómez-LahozMiguel A. OrtegaJose Maria GasallaÓscar GasullaJordi Fortuny-ProfitósFerran A. Mazaira-FontMiguel Teixidó RománAlberto ArranzJosé SanzBenjamin MuñozJuan Arévalo-SerranoJosé Miguel RodríguezCarlos Martínez-ADimitri BalomenosMelchor Álvarez-MonMDPI AGarticleSARS-CoV-2ICUinnate inflammatory responseCOVID-19cytokinesBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1675, p 1675 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 ICU innate inflammatory response COVID-19 cytokines Biology (General) QH301-705.5
spellingShingle	SARS-CoV-2 ICU innate inflammatory response COVID-19 cytokines Biology (General) QH301-705.5 Jorge Monserrat Angel Asunsolo Ana Gómez-Lahoz Miguel A. Ortega Jose Maria Gasalla Óscar Gasulla Jordi Fortuny-Profitós Ferran A. Mazaira-Font Miguel Teixidó Román Alberto Arranz José Sanz Benjamin Muñoz Juan Arévalo-Serrano José Miguel Rodríguez Carlos Martínez-A Dimitri Balomenos Melchor Álvarez-Mon Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
description	Objective: To describe the capacity of a broad spectrum of cytokines and growth factors to predict ICU admission and/or death in patients with severe COVID-19. Design: An observational, analytical, retrospective cohort study with longitudinal follow-up. Setting: Hospital Universitario Príncipe de Asturias (HUPA). Participants: 287 patients diagnosed with COVID-19 admitted to our hospital from 24 March to 8 May 2020, followed until 31 August 2020. Main outcome measures: Profiles of immune response (IR) mediators were determined using the Luminex Multiplex technique in hospitalized patients within six days of admission by examining serum levels of 62 soluble molecules classified into the three groups: adaptive IR-related cytokines (<i>n</i> = 19), innate inflammatory IR-related cytokines (<i>n</i> = 27), and growth factors (<i>n</i> = 16). Results: A statistically robust link with ICU admission and/or death was detected for increased serum levels of interleukin (IL)-6, IL-15, soluble (s) RAGE, IP10, MCP3, sIL1RII, IL-8, GCSF and MCSF and IL-10. The greatest prognostic value was observed for the marker combination IL-10, IL-6 and GCSF. Conclusions: When severe COVID-19 progresses to ICU admission and/or death there is a marked increase in serum levels of several cytokines and chemokines, mainly related to the patient’s inflammatory IR. Serum levels of IL-10, IL-6 and GCSF were most prognostic of the outcome measure.
format	article
author	Jorge Monserrat Angel Asunsolo Ana Gómez-Lahoz Miguel A. Ortega Jose Maria Gasalla Óscar Gasulla Jordi Fortuny-Profitós Ferran A. Mazaira-Font Miguel Teixidó Román Alberto Arranz José Sanz Benjamin Muñoz Juan Arévalo-Serrano José Miguel Rodríguez Carlos Martínez-A Dimitri Balomenos Melchor Álvarez-Mon
author_facet	Jorge Monserrat Angel Asunsolo Ana Gómez-Lahoz Miguel A. Ortega Jose Maria Gasalla Óscar Gasulla Jordi Fortuny-Profitós Ferran A. Mazaira-Font Miguel Teixidó Román Alberto Arranz José Sanz Benjamin Muñoz Juan Arévalo-Serrano José Miguel Rodríguez Carlos Martínez-A Dimitri Balomenos Melchor Álvarez-Mon
author_sort	Jorge Monserrat
title	Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
title_short	Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
title_full	Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
title_fullStr	Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
title_full_unstemmed	Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19
title_sort	impact of the innate inflammatory response on icu admission and death in hospitalized patients with covid-19
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b1d72c62152a471b83fc33cb7348db60
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Impact of the Innate Inflammatory Response on ICU Admission and Death in Hospitalized Patients with COVID-19

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