Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction
Abstract We investigated the impact of pre-percutaneous coronary intervention (pre-PCI) thrombolysis in myocardial infarction (TIMI) flow grade (pre-TIMI) on 3-month (3-mo) and 12-mo of dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (AMI). This was a post hoc analysis...
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2021
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oai:doaj.org-article:b1da4088b6e445f192ff4097a5cac23c2021-12-02T17:51:06ZImpact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction10.1038/s41598-021-91130-52045-2322https://doaj.org/article/b1da4088b6e445f192ff4097a5cac23c2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91130-5https://doaj.org/toc/2045-2322Abstract We investigated the impact of pre-percutaneous coronary intervention (pre-PCI) thrombolysis in myocardial infarction (TIMI) flow grade (pre-TIMI) on 3-month (3-mo) and 12-mo of dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (AMI). This was a post hoc analysis of the TICO trial. A total of 2083 patients with AMI (pre-TIMI 0/1: n = 1143; pre-TIMI 2/3: n = 940) were evaluated. The primary outcome was the occurrence of net adverse clinical events (NACE), defined as a composite of TIMI major bleeding and major adverse cardiac and cerebrovascular events (MACCE) within 12-mo following PCI. The secondary outcomes were the occurrence of the individual components of TIMI bleedings and MACCE. In the pre-TIMI 0/1 group, the primary and second outcomes were not significantly different between the 3-mo and 12-mo DAPT groups. However, in the pre-TIMI 2/3 group, the occurrences of TIMI minor (adjusted hazard ratio [aHR]: 0.294; p = 0.016) and major or minor bleeding (aHR: 0.483; p = 0.014) on intention-to-treat analysis were significantly higher in the 12-mo than in the 3-mo DAPT group. The occurrence of MACCE was similar between the two groups. A higher bleeding tendency in 12-mo DAPT compared with 3-mo DAPT was more obvious in the pre-TIMI 2/3 group than in the pre-TIMI 0/1 group. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT02494895.Yong Hoon KimAe-Young HerByeong-Keuk KimSung-Jin HongChul-Min AhnJung-Sun KimYoung-Guk KoDonghoon ChoiMyeong-Ki HongYangsoo JangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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Medicine R Science Q Yong Hoon Kim Ae-Young Her Byeong-Keuk Kim Sung-Jin Hong Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| description |
Abstract We investigated the impact of pre-percutaneous coronary intervention (pre-PCI) thrombolysis in myocardial infarction (TIMI) flow grade (pre-TIMI) on 3-month (3-mo) and 12-mo of dual antiplatelet therapy (DAPT) in patients with acute myocardial infarction (AMI). This was a post hoc analysis of the TICO trial. A total of 2083 patients with AMI (pre-TIMI 0/1: n = 1143; pre-TIMI 2/3: n = 940) were evaluated. The primary outcome was the occurrence of net adverse clinical events (NACE), defined as a composite of TIMI major bleeding and major adverse cardiac and cerebrovascular events (MACCE) within 12-mo following PCI. The secondary outcomes were the occurrence of the individual components of TIMI bleedings and MACCE. In the pre-TIMI 0/1 group, the primary and second outcomes were not significantly different between the 3-mo and 12-mo DAPT groups. However, in the pre-TIMI 2/3 group, the occurrences of TIMI minor (adjusted hazard ratio [aHR]: 0.294; p = 0.016) and major or minor bleeding (aHR: 0.483; p = 0.014) on intention-to-treat analysis were significantly higher in the 12-mo than in the 3-mo DAPT group. The occurrence of MACCE was similar between the two groups. A higher bleeding tendency in 12-mo DAPT compared with 3-mo DAPT was more obvious in the pre-TIMI 2/3 group than in the pre-TIMI 0/1 group. Clinical Trial Registration: URL: http://www.clinicaltrials.gov . Unique identifier: NCT02494895. |
| format |
article |
| author |
Yong Hoon Kim Ae-Young Her Byeong-Keuk Kim Sung-Jin Hong Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang |
| author_facet |
Yong Hoon Kim Ae-Young Her Byeong-Keuk Kim Sung-Jin Hong Chul-Min Ahn Jung-Sun Kim Young-Guk Ko Donghoon Choi Myeong-Ki Hong Yangsoo Jang |
| author_sort |
Yong Hoon Kim |
| title |
Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| title_short |
Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| title_full |
Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| title_fullStr |
Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| title_full_unstemmed |
Impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| title_sort |
impact of preprocedural coronary flow grade on duration of dual antiplatelet therapy in acute myocardial infarction |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/b1da4088b6e445f192ff4097a5cac23c |
| work_keys_str_mv |
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