Total glucose control: the role of post-prandial glucose

The basis of strict glucose control and the achievement of a favorable HgbAlc must involve the control of both fasting and post-prandial glucose levels. Most of the day is spent in the post-prandial state. The most important predictor of post prandial glycemia is the pre-prandial glucose. Glucose co...

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Autor principal:	PAUL S JELLINGER
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2004
Materias:	постпрандиальная гипергликемия сердечно-сосудистый риск осложнения сахарный диабет Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/b1daab6a7f67466daf0c6561de86b2ed
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spelling	oai:doaj.org-article:b1daab6a7f67466daf0c6561de86b2ed2021-11-14T09:00:09ZTotal glucose control: the role of post-prandial glucose2072-03512072-037810.14341/2072-0351-5601https://doaj.org/article/b1daab6a7f67466daf0c6561de86b2ed2004-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5601https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378The basis of strict glucose control and the achievement of a favorable HgbAlc must involve the control of both fasting and post-prandial glucose levels. Most of the day is spent in the post-prandial state. The most important predictor of post prandial glycemia is the pre-prandial glucose. Glucose control in the United States is far from optimal with a minority of patients achieving either the ADA goal of 7.0% or the ACE/AACE goal of 6.5%. There is evidence that post-meal glucose has a better correlation with A1C than fasting glucose levels especially when the A1C is less than 8%. A reduced early insulin release leads to high postprandial glucose. The evidence that lowering Hgb A1C results in lower microvascular risk is substantial. The DCC T demonstrated a clear association, of retinopathy with A1C . The study also demonstrated that for the same Al C, intensive glucose control using short-acting insulin pre-meals was associated with reduced complications compared to conventional treatment without short acting insulin. Further evidence from the Kumamoto Study and the UKPDS confirm reduced microvascular complications with lower A1C levels. Elevated mealtime glucose is an unappreciated concern at all levels of A1C including A1C levels at normal or near normal values. Elevated mealtime glucose is of special concern in the elderly. There is strong epidemiologic evidence linking post challenge hyperglycemia to macro-vascular risk. These include the Rancho Bernardo study the Honolulu Heart Study, the Paris Prospective Heart Study, The Diabetes Intervention Study, and the DECODE Study. There are many other studies going back to the 1980s that relate post-challenge or post-prandial blood glucose to cardiovascular disease risk and mortality. Possible effects of acute hyperglycemia responsible for increased microvascular and macrovascular risk include endothelial dysfunction, increased oxidative load, a pro-inflammatory state, protein glycosylation and altered coagulation. There is evidence that oral glucose loading adversely affects endothelial function. Oxidative load in the form of reactive oxygen species is increased following a glucose challenge. The pro-inflammatory state relates to quintiles of dietary glycemic load as it does to the 2- hour post challenge glucose category. There is evidence that in intimal media thickness increases more with the 2 hour glucose than A 1С. In summary, post mealtime glucose spikes are to be prevented because lowering A1C reduces microvascular complications, A1C reflects post mealtime glucose as well as fasting plasma group glucose, elevated post-meal glucose is a highly prevalent issue and elevated blood glucose 2 hours after a glucose load is associated with increased risk of death independent of fasting blood glucose. The Epic- Norfork study raises questions as to the level of A1C associated with risk.PAUL S JELLINGEREndocrinology Research Centrearticleпостпрандиальная гипергликемиясердечно-сосудистый рискосложнениясахарный диабетNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 7, Iss 2, Pp 4-8 (2004)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	постпрандиальная гипергликемия сердечно-сосудистый риск осложнения сахарный диабет Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	постпрандиальная гипергликемия сердечно-сосудистый риск осложнения сахарный диабет Nutritional diseases. Deficiency diseases RC620-627 PAUL S JELLINGER Total glucose control: the role of post-prandial glucose
description	The basis of strict glucose control and the achievement of a favorable HgbAlc must involve the control of both fasting and post-prandial glucose levels. Most of the day is spent in the post-prandial state. The most important predictor of post prandial glycemia is the pre-prandial glucose. Glucose control in the United States is far from optimal with a minority of patients achieving either the ADA goal of 7.0% or the ACE/AACE goal of 6.5%. There is evidence that post-meal glucose has a better correlation with A1C than fasting glucose levels especially when the A1C is less than 8%. A reduced early insulin release leads to high postprandial glucose. The evidence that lowering Hgb A1C results in lower microvascular risk is substantial. The DCC T demonstrated a clear association, of retinopathy with A1C . The study also demonstrated that for the same Al C, intensive glucose control using short-acting insulin pre-meals was associated with reduced complications compared to conventional treatment without short acting insulin. Further evidence from the Kumamoto Study and the UKPDS confirm reduced microvascular complications with lower A1C levels. Elevated mealtime glucose is an unappreciated concern at all levels of A1C including A1C levels at normal or near normal values. Elevated mealtime glucose is of special concern in the elderly. There is strong epidemiologic evidence linking post challenge hyperglycemia to macro-vascular risk. These include the Rancho Bernardo study the Honolulu Heart Study, the Paris Prospective Heart Study, The Diabetes Intervention Study, and the DECODE Study. There are many other studies going back to the 1980s that relate post-challenge or post-prandial blood glucose to cardiovascular disease risk and mortality. Possible effects of acute hyperglycemia responsible for increased microvascular and macrovascular risk include endothelial dysfunction, increased oxidative load, a pro-inflammatory state, protein glycosylation and altered coagulation. There is evidence that oral glucose loading adversely affects endothelial function. Oxidative load in the form of reactive oxygen species is increased following a glucose challenge. The pro-inflammatory state relates to quintiles of dietary glycemic load as it does to the 2- hour post challenge glucose category. There is evidence that in intimal media thickness increases more with the 2 hour glucose than A 1С. In summary, post mealtime glucose spikes are to be prevented because lowering A1C reduces microvascular complications, A1C reflects post mealtime glucose as well as fasting plasma group glucose, elevated post-meal glucose is a highly prevalent issue and elevated blood glucose 2 hours after a glucose load is associated with increased risk of death independent of fasting blood glucose. The Epic- Norfork study raises questions as to the level of A1C associated with risk.
format	article
author	PAUL S JELLINGER
author_facet	PAUL S JELLINGER
author_sort	PAUL S JELLINGER
title	Total glucose control: the role of post-prandial glucose
title_short	Total glucose control: the role of post-prandial glucose
title_full	Total glucose control: the role of post-prandial glucose
title_fullStr	Total glucose control: the role of post-prandial glucose
title_full_unstemmed	Total glucose control: the role of post-prandial glucose
title_sort	total glucose control: the role of post-prandial glucose
publisher	Endocrinology Research Centre
publishDate	2004
url	https://doaj.org/article/b1daab6a7f67466daf0c6561de86b2ed
work_keys_str_mv	AT paulsjellinger totalglucosecontroltheroleofpostprandialglucose
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Total glucose control: the role of post-prandial glucose

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