Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring

Several studies suggest that the maternal protein content and source can affect the offspring’s health. However, the chronic impact of maternal quality and quantity protein restriction, and reversible changes upon rehabilitation, if any, in the offspring, remains elusive. This study examined the eff...

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Autores principales:	Pandarinath Savitikadi, Raghu Pullakhandam, Bharati Kulkarni, Boiroju Naveen Kumar, Geereddy Bhanuprakash Reddy, Vadde Sudhakar Reddy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	low-quality protein low-protein wheat gluten growth rehabilitation body composition Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b1e1f67e3e9d4e78a56d7afaa8584e51
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spelling	oai:doaj.org-article:b1e1f67e3e9d4e78a56d7afaa8584e512021-11-25T18:36:59ZChronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring10.3390/nu131141292072-6643https://doaj.org/article/b1e1f67e3e9d4e78a56d7afaa8584e512021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4129https://doaj.org/toc/2072-6643Several studies suggest that the maternal protein content and source can affect the offspring’s health. However, the chronic impact of maternal quality and quantity protein restriction, and reversible changes upon rehabilitation, if any, in the offspring, remains elusive. This study examined the effects of maternal low-quality protein (LQP) and low-protein (LP) intake from preconception to post-weaning, followed by rehabilitation from weaning, on body composition, glucose-homeostasis, and metabolic factors in rat offspring. Wistar rats were exposed to normal protein (NP; 20% casein), LQP (20% wheat gluten) or LP (8% casein) isocaloric diets for 7 weeks before pregnancy until lactation. After weaning, the offspring were exposed to five diets: NP, LQP, LQPR (LQP rehabilitated with NP), LP, and LPR (LP rehabilitated with NP) for 16 weeks. Body composition, glucose-homeostasis, lipids, and plasma hormones were investigated. The LQP and LP offspring had lower bodyweight, fat and lean mass, insulin and HOMA-IR than the NP. The LQP offspring had higher cholesterol, T3 and T4, and lower triacylglycerides and glucose, while these were unaltered in LP compared to NP. The majority of the above outcomes were reversed upon rehabilitation. These results suggest that the chronic exposure of rats to maternal LQP and LP diets induced differential adverse effects by influencing body composition and metabolism, which were reversed upon rehabilitation.Pandarinath SavitikadiRaghu PullakhandamBharati KulkarniBoiroju Naveen KumarGeereddy Bhanuprakash ReddyVadde Sudhakar ReddyMDPI AGarticlelow-quality proteinlow-proteinwheat glutengrowthrehabilitationbody compositionNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4129, p 4129 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	low-quality protein low-protein wheat gluten growth rehabilitation body composition Nutrition. Foods and food supply TX341-641
spellingShingle	low-quality protein low-protein wheat gluten growth rehabilitation body composition Nutrition. Foods and food supply TX341-641 Pandarinath Savitikadi Raghu Pullakhandam Bharati Kulkarni Boiroju Naveen Kumar Geereddy Bhanuprakash Reddy Vadde Sudhakar Reddy Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
description	Several studies suggest that the maternal protein content and source can affect the offspring’s health. However, the chronic impact of maternal quality and quantity protein restriction, and reversible changes upon rehabilitation, if any, in the offspring, remains elusive. This study examined the effects of maternal low-quality protein (LQP) and low-protein (LP) intake from preconception to post-weaning, followed by rehabilitation from weaning, on body composition, glucose-homeostasis, and metabolic factors in rat offspring. Wistar rats were exposed to normal protein (NP; 20% casein), LQP (20% wheat gluten) or LP (8% casein) isocaloric diets for 7 weeks before pregnancy until lactation. After weaning, the offspring were exposed to five diets: NP, LQP, LQPR (LQP rehabilitated with NP), LP, and LPR (LP rehabilitated with NP) for 16 weeks. Body composition, glucose-homeostasis, lipids, and plasma hormones were investigated. The LQP and LP offspring had lower bodyweight, fat and lean mass, insulin and HOMA-IR than the NP. The LQP offspring had higher cholesterol, T3 and T4, and lower triacylglycerides and glucose, while these were unaltered in LP compared to NP. The majority of the above outcomes were reversed upon rehabilitation. These results suggest that the chronic exposure of rats to maternal LQP and LP diets induced differential adverse effects by influencing body composition and metabolism, which were reversed upon rehabilitation.
format	article
author	Pandarinath Savitikadi Raghu Pullakhandam Bharati Kulkarni Boiroju Naveen Kumar Geereddy Bhanuprakash Reddy Vadde Sudhakar Reddy
author_facet	Pandarinath Savitikadi Raghu Pullakhandam Bharati Kulkarni Boiroju Naveen Kumar Geereddy Bhanuprakash Reddy Vadde Sudhakar Reddy
author_sort	Pandarinath Savitikadi
title	Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
title_short	Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
title_full	Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
title_fullStr	Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
title_full_unstemmed	Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring
title_sort	chronic effects of maternal low-protein and low-quality protein diets on body composition, glucose-homeostasis and metabolic factors, followed by reversible changes upon rehabilitation in adult rat offspring
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/b1e1f67e3e9d4e78a56d7afaa8584e51
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Chronic Effects of Maternal Low-Protein and Low-Quality Protein Diets on Body Composition, Glucose-Homeostasis and Metabolic Factors, Followed by Reversible Changes upon Rehabilitation in Adult Rat Offspring

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