Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notu...

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Autores principales:	Lydie Couturier, Khalil Mazouni, Francis Corson, François Schweisguth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1e2fcacebd2420186e6c4bfdc70b544
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spelling	oai:doaj.org-article:b1e2fcacebd2420186e6c4bfdc70b5442021-12-02T17:33:22ZRegulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila10.1038/s41467-019-11477-22041-1723https://doaj.org/article/b1e2fcacebd2420186e6c4bfdc70b5442019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11477-2https://doaj.org/toc/2041-1723The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.Lydie CouturierKhalil MazouniFrancis CorsonFrançois SchweisguthNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lydie Couturier Khalil Mazouni Francis Corson François Schweisguth Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
description	The patterning of sensory bristles on the dorsal thorax of flies is regulated by two transcription factor families but the dynamics of this regulation is unclear. Here, the authors visualize seven E(spl)-HLH proteins, showing their regulated expression promotes mutual inhibition by Notch during notum patterning.
format	article
author	Lydie Couturier Khalil Mazouni Francis Corson François Schweisguth
author_facet	Lydie Couturier Khalil Mazouni Francis Corson François Schweisguth
author_sort	Lydie Couturier
title	Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_short	Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_full	Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_fullStr	Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_full_unstemmed	Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila
title_sort	regulation of notch output dynamics via specific e(spl)-hlh factors during bristle patterning in drosophila
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/b1e2fcacebd2420186e6c4bfdc70b544
work_keys_str_mv	AT lydiecouturier regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila AT khalilmazouni regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila AT franciscorson regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila AT francoisschweisguth regulationofnotchoutputdynamicsviaspecificesplhlhfactorsduringbristlepatterningindrosophila
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Regulation of Notch output dynamics via specific E(spl)-HLH factors during bristle patterning in Drosophila

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