Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.

Biomechanical properties are an excellent health marker of biological tissues, however they are challenging to be measured in-vivo. Non-invasive approaches to assess tissue biomechanics have been suggested, but there is a clear need for more accurate techniques for diagnosis, surgical guidance and t...

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Autores principales:	Sabine Kling, Nandor Bekesi, Carlos Dorronsoro, Daniel Pascual, Susana Marcos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1e3a71ee52c41789618845be7d8c445
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spelling	oai:doaj.org-article:b1e3a71ee52c41789618845be7d8c4452021-11-25T06:04:48ZCorneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.1932-620310.1371/journal.pone.0104904https://doaj.org/article/b1e3a71ee52c41789618845be7d8c4452014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25121496/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Biomechanical properties are an excellent health marker of biological tissues, however they are challenging to be measured in-vivo. Non-invasive approaches to assess tissue biomechanics have been suggested, but there is a clear need for more accurate techniques for diagnosis, surgical guidance and treatment evaluation. Recently air-puff systems have been developed to study the dynamic tissue response, nevertheless the experimental geometrical observations lack from an analysis that addresses specifically the inherent dynamic properties. In this study a viscoelastic finite element model was built that predicts the experimental corneal deformation response to an air-puff for different conditions. A sensitivity analysis reveals significant contributions to corneal deformation of intraocular pressure and corneal thickness, besides corneal biomechanical properties. The results show the capability of dynamic imaging to reveal inherent biomechanical properties in vivo. Estimates of corneal biomechanical parameters will contribute to the basic understanding of corneal structure, shape and integrity and increase the predictability of corneal surgery.Sabine KlingNandor BekesiCarlos DorronsoroDaniel PascualSusana MarcosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104904 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sabine Kling Nandor Bekesi Carlos Dorronsoro Daniel Pascual Susana Marcos Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
description	Biomechanical properties are an excellent health marker of biological tissues, however they are challenging to be measured in-vivo. Non-invasive approaches to assess tissue biomechanics have been suggested, but there is a clear need for more accurate techniques for diagnosis, surgical guidance and treatment evaluation. Recently air-puff systems have been developed to study the dynamic tissue response, nevertheless the experimental geometrical observations lack from an analysis that addresses specifically the inherent dynamic properties. In this study a viscoelastic finite element model was built that predicts the experimental corneal deformation response to an air-puff for different conditions. A sensitivity analysis reveals significant contributions to corneal deformation of intraocular pressure and corneal thickness, besides corneal biomechanical properties. The results show the capability of dynamic imaging to reveal inherent biomechanical properties in vivo. Estimates of corneal biomechanical parameters will contribute to the basic understanding of corneal structure, shape and integrity and increase the predictability of corneal surgery.
format	article
author	Sabine Kling Nandor Bekesi Carlos Dorronsoro Daniel Pascual Susana Marcos
author_facet	Sabine Kling Nandor Bekesi Carlos Dorronsoro Daniel Pascual Susana Marcos
author_sort	Sabine Kling
title	Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
title_short	Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
title_full	Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
title_fullStr	Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
title_full_unstemmed	Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
title_sort	corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/b1e3a71ee52c41789618845be7d8c445
work_keys_str_mv	AT sabinekling cornealviscoelasticpropertiesfromfiniteelementanalysisofinvivoairpuffdeformation AT nandorbekesi cornealviscoelasticpropertiesfromfiniteelementanalysisofinvivoairpuffdeformation AT carlosdorronsoro cornealviscoelasticpropertiesfromfiniteelementanalysisofinvivoairpuffdeformation AT danielpascual cornealviscoelasticpropertiesfromfiniteelementanalysisofinvivoairpuffdeformation AT susanamarcos cornealviscoelasticpropertiesfromfiniteelementanalysisofinvivoairpuffdeformation
_version_	1718414240990101504

Corneal viscoelastic properties from finite-element analysis of in vivo air-puff deformation.

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