RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia
Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics.
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Nature Portfolio
2017
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oai:doaj.org-article:b1e79a966ad24c1db61ab521bffa8d402021-12-02T17:06:23ZRAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia10.1038/s41467-017-02177-w2041-1723https://doaj.org/article/b1e79a966ad24c1db61ab521bffa8d402017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02177-whttps://doaj.org/toc/2041-1723Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics.Daniel B. LipkaTania WitteReka TothJing YangManuel WiesenfarthPeter NöllkeAlexandra FischerDavid BrocksZuguang GuJeongbin ParkBrigitte StrahmMarcin WlodarskiAyami YoshimiRainer ClausMichael LübbertHauke BuschMelanie BoerriesMark HartmannMaximilian SchönungUmut KilikJens LangsteinJustyna A. WierzbinskaCaroline PabstSwati GargAlbert CataláBarbara De MoerlooseMichael DworzakHenrik HasleFranco LocatelliRiccardo MasettiMarkus SchmuggeOwen SmithJan StaryMarek UssowiczMarry M. van den Heuvel-EibrinkYassen AssenovMatthias SchlesnerCharlotte NiemeyerChristian FlothoChristoph PlassNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
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Science Q Daniel B. Lipka Tania Witte Reka Toth Jing Yang Manuel Wiesenfarth Peter Nöllke Alexandra Fischer David Brocks Zuguang Gu Jeongbin Park Brigitte Strahm Marcin Wlodarski Ayami Yoshimi Rainer Claus Michael Lübbert Hauke Busch Melanie Boerries Mark Hartmann Maximilian Schönung Umut Kilik Jens Langstein Justyna A. Wierzbinska Caroline Pabst Swati Garg Albert Catalá Barbara De Moerloose Michael Dworzak Henrik Hasle Franco Locatelli Riccardo Masetti Markus Schmugge Owen Smith Jan Stary Marek Ussowicz Marry M. van den Heuvel-Eibrink Yassen Assenov Matthias Schlesner Charlotte Niemeyer Christian Flotho Christoph Plass RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| description |
Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics. |
| format |
article |
| author |
Daniel B. Lipka Tania Witte Reka Toth Jing Yang Manuel Wiesenfarth Peter Nöllke Alexandra Fischer David Brocks Zuguang Gu Jeongbin Park Brigitte Strahm Marcin Wlodarski Ayami Yoshimi Rainer Claus Michael Lübbert Hauke Busch Melanie Boerries Mark Hartmann Maximilian Schönung Umut Kilik Jens Langstein Justyna A. Wierzbinska Caroline Pabst Swati Garg Albert Catalá Barbara De Moerloose Michael Dworzak Henrik Hasle Franco Locatelli Riccardo Masetti Markus Schmugge Owen Smith Jan Stary Marek Ussowicz Marry M. van den Heuvel-Eibrink Yassen Assenov Matthias Schlesner Charlotte Niemeyer Christian Flotho Christoph Plass |
| author_facet |
Daniel B. Lipka Tania Witte Reka Toth Jing Yang Manuel Wiesenfarth Peter Nöllke Alexandra Fischer David Brocks Zuguang Gu Jeongbin Park Brigitte Strahm Marcin Wlodarski Ayami Yoshimi Rainer Claus Michael Lübbert Hauke Busch Melanie Boerries Mark Hartmann Maximilian Schönung Umut Kilik Jens Langstein Justyna A. Wierzbinska Caroline Pabst Swati Garg Albert Catalá Barbara De Moerloose Michael Dworzak Henrik Hasle Franco Locatelli Riccardo Masetti Markus Schmugge Owen Smith Jan Stary Marek Ussowicz Marry M. van den Heuvel-Eibrink Yassen Assenov Matthias Schlesner Charlotte Niemeyer Christian Flotho Christoph Plass |
| author_sort |
Daniel B. Lipka |
| title |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| title_short |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| title_full |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| title_fullStr |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| title_full_unstemmed |
RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| title_sort |
ras-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/b1e79a966ad24c1db61ab521bffa8d40 |
| work_keys_str_mv |
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