Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol

In the present study, three north-western Himalayan medicinal plants, Ocimum sanctum, Terminalia bellerica and Terminalia chebula were used to evaluate the effectiveness of choline chloride based natural deep eutectic solvents (NADESs) in extracting the polyphenolic compounds. The natural deep eutec...

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Autores principales:	Pooja Choudhary, Sanjay Guleria, Neha Sharma, K.H. Salaria, Rashmi Chalotra, Villayat Ali, Dhiraj Vyas
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	NADESs HPLC Choline chloride Malic acid Antioxidant activity α-glucosidase inhibitory activity Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/b1e79c9137694cba937934cbfb352d58
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spelling	oai:doaj.org-article:b1e79c9137694cba937934cbfb352d582021-12-02T05:03:41ZComparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol2666-086510.1016/j.crgsc.2021.100224https://doaj.org/article/b1e79c9137694cba937934cbfb352d582021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2666086521001715https://doaj.org/toc/2666-0865In the present study, three north-western Himalayan medicinal plants, Ocimum sanctum, Terminalia bellerica and Terminalia chebula were used to evaluate the effectiveness of choline chloride based natural deep eutectic solvents (NADESs) in extracting the polyphenolic compounds. The natural deep eutectic solvents used in the study were choline chloride:glucose: water, choline chloride:fructose:water, choline chloride: xylose: water, choline chloride:glycerol:water and choline chloride:malic acid:water.The results of the above study showed that all the eutectic solvents were more effective in extracting phenolic compounds than methanol, however, choline chloride:malic acid:water based NADES was most effective among all the NADESs tested and methanol. Additionally, profiling of phenolic compounds in extracts obtained by choline chloride:malic acid:water and methanol was also carried out using HPLC analysis. It was also observed that extracts possessing higher polyphenolic content showed higher DPPH radical scavenging activity, ferric reducing antioxidant power, reducing power and α-glucosidase inhibitory activity. Our results suggests that natural deep eutectic solvents offers efficient and safe alternative to methanol for extraction of phenolic compounds from medicinal plants.Pooja ChoudharySanjay GuleriaNeha SharmaK.H. SalariaRashmi ChalotraVillayat AliDhiraj VyasElsevierarticleNADESsHPLCCholine chlorideMalic acidAntioxidant activityα-glucosidase inhibitory activityChemistryQD1-999ENCurrent Research in Green and Sustainable Chemistry, Vol 4, Iss , Pp 100224- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	NADESs HPLC Choline chloride Malic acid Antioxidant activity α-glucosidase inhibitory activity Chemistry QD1-999
spellingShingle	NADESs HPLC Choline chloride Malic acid Antioxidant activity α-glucosidase inhibitory activity Chemistry QD1-999 Pooja Choudhary Sanjay Guleria Neha Sharma K.H. Salaria Rashmi Chalotra Villayat Ali Dhiraj Vyas Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
description	In the present study, three north-western Himalayan medicinal plants, Ocimum sanctum, Terminalia bellerica and Terminalia chebula were used to evaluate the effectiveness of choline chloride based natural deep eutectic solvents (NADESs) in extracting the polyphenolic compounds. The natural deep eutectic solvents used in the study were choline chloride:glucose: water, choline chloride:fructose:water, choline chloride: xylose: water, choline chloride:glycerol:water and choline chloride:malic acid:water.The results of the above study showed that all the eutectic solvents were more effective in extracting phenolic compounds than methanol, however, choline chloride:malic acid:water based NADES was most effective among all the NADESs tested and methanol. Additionally, profiling of phenolic compounds in extracts obtained by choline chloride:malic acid:water and methanol was also carried out using HPLC analysis. It was also observed that extracts possessing higher polyphenolic content showed higher DPPH radical scavenging activity, ferric reducing antioxidant power, reducing power and α-glucosidase inhibitory activity. Our results suggests that natural deep eutectic solvents offers efficient and safe alternative to methanol for extraction of phenolic compounds from medicinal plants.
format	article
author	Pooja Choudhary Sanjay Guleria Neha Sharma K.H. Salaria Rashmi Chalotra Villayat Ali Dhiraj Vyas
author_facet	Pooja Choudhary Sanjay Guleria Neha Sharma K.H. Salaria Rashmi Chalotra Villayat Ali Dhiraj Vyas
author_sort	Pooja Choudhary
title	Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
title_short	Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
title_full	Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
title_fullStr	Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
title_full_unstemmed	Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
title_sort	comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/b1e79c9137694cba937934cbfb352d58
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Comparative phenolic content and antioxidant activity of some medicinal plant extracts prepared by choline chloride based green solvents and methanol

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