TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription
Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity.
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Nature Portfolio
2019
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oai:doaj.org-article:b1e7a79e5d3d4b7f8ef165185b4670132021-12-02T13:23:54ZTRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription10.1038/s41467-019-13700-62041-1723https://doaj.org/article/b1e7a79e5d3d4b7f8ef165185b4670132019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13700-6https://doaj.org/toc/2041-1723Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity.Jin-mei YuWei SunZhen-he WangXiao LiangFang HuaKe LiXiao-xi LvXiao-wei ZhangYu-ying LiuJiao-jiao YuShan-shan LiuShuang ShangFeng WangZhao-na YangChen-xi ZhaoXue-ying HouPing-ping LiBo HuangBing CuiZhuo-Wei HuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jin-mei Yu Wei Sun Zhen-he Wang Xiao Liang Fang Hua Ke Li Xiao-xi Lv Xiao-wei Zhang Yu-ying Liu Jiao-jiao Yu Shan-shan Liu Shuang Shang Feng Wang Zhao-na Yang Chen-xi Zhao Xue-ying Hou Ping-ping Li Bo Huang Bing Cui Zhuo-Wei Hu TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| description |
Cancer stem cells contribute to breast cancer metastasis and recurrence. Here the authors show that TRIB3 enhances breast cancer stemness through interaction with AKT to promote FOXO1 stability, which then increases SOX2 activity. |
| format |
article |
| author |
Jin-mei Yu Wei Sun Zhen-he Wang Xiao Liang Fang Hua Ke Li Xiao-xi Lv Xiao-wei Zhang Yu-ying Liu Jiao-jiao Yu Shan-shan Liu Shuang Shang Feng Wang Zhao-na Yang Chen-xi Zhao Xue-ying Hou Ping-ping Li Bo Huang Bing Cui Zhuo-Wei Hu |
| author_facet |
Jin-mei Yu Wei Sun Zhen-he Wang Xiao Liang Fang Hua Ke Li Xiao-xi Lv Xiao-wei Zhang Yu-ying Liu Jiao-jiao Yu Shan-shan Liu Shuang Shang Feng Wang Zhao-na Yang Chen-xi Zhao Xue-ying Hou Ping-ping Li Bo Huang Bing Cui Zhuo-Wei Hu |
| author_sort |
Jin-mei Yu |
| title |
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| title_short |
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| title_full |
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| title_fullStr |
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| title_full_unstemmed |
TRIB3 supports breast cancer stemness by suppressing FOXO1 degradation and enhancing SOX2 transcription |
| title_sort |
trib3 supports breast cancer stemness by suppressing foxo1 degradation and enhancing sox2 transcription |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/b1e7a79e5d3d4b7f8ef165185b467013 |
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