CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension

T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+rete...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Yunmeng Liu, Tonya M. Rafferty, Sung W. Rhee, Jessica S. Webber, Li Song, Benjamin Ko, Robert S. Hoover, Beixiang He, Shengyu Mu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Q
Acceso en línea:https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:b1e9f4a1108846c78a1934ac7851a680
record_format dspace
spelling oai:doaj.org-article:b1e9f4a1108846c78a1934ac7851a6802021-12-02T15:37:02ZCD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension10.1038/ncomms140372041-1723https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a6802017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14037https://doaj.org/toc/2041-1723T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension.Yunmeng LiuTonya M. RaffertySung W. RheeJessica S. WebberLi SongBenjamin KoRobert S. HooverBeixiang HeShengyu MuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yunmeng Liu
Tonya M. Rafferty
Sung W. Rhee
Jessica S. Webber
Li Song
Benjamin Ko
Robert S. Hoover
Beixiang He
Shengyu Mu
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
description T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension.
format article
author Yunmeng Liu
Tonya M. Rafferty
Sung W. Rhee
Jessica S. Webber
Li Song
Benjamin Ko
Robert S. Hoover
Beixiang He
Shengyu Mu
author_facet Yunmeng Liu
Tonya M. Rafferty
Sung W. Rhee
Jessica S. Webber
Li Song
Benjamin Ko
Robert S. Hoover
Beixiang He
Shengyu Mu
author_sort Yunmeng Liu
title CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_short CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_full CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_fullStr CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_full_unstemmed CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_sort cd8+ t cells stimulate na-cl co-transporter ncc in distal convoluted tubules leading to salt-sensitive hypertension
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680
work_keys_str_mv AT yunmengliu cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT tonyamrafferty cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT sungwrhee cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT jessicaswebber cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT lisong cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT benjaminko cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT robertshoover cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT beixianghe cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
AT shengyumu cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension
_version_ 1718386253434454016