CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension

T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+rete...

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Autores principales:	Yunmeng Liu, Tonya M. Rafferty, Sung W. Rhee, Jessica S. Webber, Li Song, Benjamin Ko, Robert S. Hoover, Beixiang He, Shengyu Mu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680
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spelling	oai:doaj.org-article:b1e9f4a1108846c78a1934ac7851a6802021-12-02T15:37:02ZCD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension10.1038/ncomms140372041-1723https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a6802017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14037https://doaj.org/toc/2041-1723T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension.Yunmeng LiuTonya M. RaffertySung W. RheeJessica S. WebberLi SongBenjamin KoRobert S. HooverBeixiang HeShengyu MuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
description	T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension.
format	article
author	Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu
author_facet	Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu
author_sort	Yunmeng Liu
title	CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_short	CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_full	CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_fullStr	CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_full_unstemmed	CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
title_sort	cd8+ t cells stimulate na-cl co-transporter ncc in distal convoluted tubules leading to salt-sensitive hypertension
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680
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CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension

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