CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension
T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+rete...
Guardado en:
Autores principales: | , , , , , , , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
|
Materias: | |
Acceso en línea: | https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:b1e9f4a1108846c78a1934ac7851a680 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:b1e9f4a1108846c78a1934ac7851a6802021-12-02T15:37:02ZCD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension10.1038/ncomms140372041-1723https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a6802017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14037https://doaj.org/toc/2041-1723T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension.Yunmeng LiuTonya M. RaffertySung W. RheeJessica S. WebberLi SongBenjamin KoRobert S. HooverBeixiang HeShengyu MuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Science Q |
spellingShingle |
Science Q Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
description |
T cells contribute to development of high blood pressure but their role in salt-sensitive hypertension is less clear. Liuet al. show that CD8+ T cells upregulate and activate Na-Cl co-transporter NCC in distal convoluted tubules via direct cell-cell contact and ROS-Src activation, leading to Na+retention and salt-sensitive hypertension. |
format |
article |
author |
Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu |
author_facet |
Yunmeng Liu Tonya M. Rafferty Sung W. Rhee Jessica S. Webber Li Song Benjamin Ko Robert S. Hoover Beixiang He Shengyu Mu |
author_sort |
Yunmeng Liu |
title |
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
title_short |
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
title_full |
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
title_fullStr |
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
title_full_unstemmed |
CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension |
title_sort |
cd8+ t cells stimulate na-cl co-transporter ncc in distal convoluted tubules leading to salt-sensitive hypertension |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/b1e9f4a1108846c78a1934ac7851a680 |
work_keys_str_mv |
AT yunmengliu cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT tonyamrafferty cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT sungwrhee cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT jessicaswebber cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT lisong cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT benjaminko cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT robertshoover cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT beixianghe cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension AT shengyumu cd8tcellsstimulatenaclcotransporternccindistalconvolutedtubulesleadingtosaltsensitivehypertension |
_version_ |
1718386253434454016 |