Brain-targeted drug delivery by manipulating protein corona functions

Brain-targeted drug delivery by manipulating protein corona functions

Plasma proteins may severely affect the in vivo performance of liposomes. Here, the authors develop bio-inspired liposomes that specifically absorb brain-targeted apolipoproteins and preserve their bioactivities, thereby achieving efficient brain targeting with minor influence on immunocompatibility...

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Autores principales: Zui Zhang, Juan Guan, Zhuxuan Jiang, Yang Yang, Jican Liu, Wei Hua, Ying Mao, Cheng Li, Weiyue Lu, Jun Qian, Changyou Zhan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Q
Acceso en línea:https://doaj.org/article/b1ea7b0d338d4e65ab52310d8be62181
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spelling oai:doaj.org-article:b1ea7b0d338d4e65ab52310d8be621812021-12-02T16:57:55ZBrain-targeted drug delivery by manipulating protein corona functions10.1038/s41467-019-11593-z2041-1723https://doaj.org/article/b1ea7b0d338d4e65ab52310d8be621812019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11593-zhttps://doaj.org/toc/2041-1723Plasma proteins may severely affect the in vivo performance of liposomes. Here, the authors develop bio-inspired liposomes that specifically absorb brain-targeted apolipoproteins and preserve their bioactivities, thereby achieving efficient brain targeting with minor influence on immunocompatibility of liposomes.Zui ZhangJuan GuanZhuxuan JiangYang YangJican LiuWei HuaYing MaoCheng LiWeiyue LuJun QianChangyou ZhanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zui Zhang
Juan Guan
Zhuxuan Jiang
Yang Yang
Jican Liu
Wei Hua
Ying Mao
Cheng Li
Weiyue Lu
Jun Qian
Changyou Zhan
Brain-targeted drug delivery by manipulating protein corona functions
description Plasma proteins may severely affect the in vivo performance of liposomes. Here, the authors develop bio-inspired liposomes that specifically absorb brain-targeted apolipoproteins and preserve their bioactivities, thereby achieving efficient brain targeting with minor influence on immunocompatibility of liposomes.
format article
author Zui Zhang
Juan Guan
Zhuxuan Jiang
Yang Yang
Jican Liu
Wei Hua
Ying Mao
Cheng Li
Weiyue Lu
Jun Qian
Changyou Zhan
author_facet Zui Zhang
Juan Guan
Zhuxuan Jiang
Yang Yang
Jican Liu
Wei Hua
Ying Mao
Cheng Li
Weiyue Lu
Jun Qian
Changyou Zhan
author_sort Zui Zhang
title Brain-targeted drug delivery by manipulating protein corona functions
title_short Brain-targeted drug delivery by manipulating protein corona functions
title_full Brain-targeted drug delivery by manipulating protein corona functions
title_fullStr Brain-targeted drug delivery by manipulating protein corona functions
title_full_unstemmed Brain-targeted drug delivery by manipulating protein corona functions
title_sort brain-targeted drug delivery by manipulating protein corona functions
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/b1ea7b0d338d4e65ab52310d8be62181
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AT juanguan braintargeteddrugdeliverybymanipulatingproteincoronafunctions
AT zhuxuanjiang braintargeteddrugdeliverybymanipulatingproteincoronafunctions
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