SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME

Aim of study: to examine the features of expression of CD-markers of blood mononuclear leukocytes and their functional activity in the metabolic syndrome. Conducted a cross-sectional (transverse) study of 76 patients with essential hypertension (EH) II stage (BP <180/110 mm Hg.) [10] in conju...

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Autores principales:	I. D. Bespalovа, N. V. Ryazantseva, V. V. Kalyuzhin, B. Yu. Murashev, I. A. Osikhov, Y. A. Medyantsev, D. S. Afanas’eva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	metabolic syndrome inflammation mononuclear leukocytes cd-markers reactive oxygen species Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/b1ed2388de0e40e0893f59f97fe2d658
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spelling	oai:doaj.org-article:b1ed2388de0e40e0893f59f97fe2d6582021-11-18T08:03:43ZSUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME1563-06252313-741X10.15789/1563-0625-2014-4-345-352https://doaj.org/article/b1ed2388de0e40e0893f59f97fe2d6582014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/700https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAim of study: to examine the features of expression of CD-markers of blood mononuclear leukocytes and their functional activity in the metabolic syndrome. Conducted a cross-sectional (transverse) study of 76 patients with essential hypertension (EH) II stage (BP <180/110 mm Hg.) [10] in conjunction with the metabolic syndrome and 20 people, formed the control group. Along with a complete clinical, laboratory and instrumental examination taken in a specialized cardiological clinic was conducted determination of surface markers of lymphocytes CD4+, CD8+ and monocytes CD36+ and assessment of the level of spontaneous production of reactive oxygen blood mononuclear leukocytes. Found that in patients with the metabolic syndrome compared with the control group the proportion of CD4+ lymphocytes and the level of spontaneous ROS production by mononuclear leukocytes significantly higher. The positive correlated interconnection between these indicators and the number of CD36+ monocytes with the majority of clinical and metabolic markers of MS confirmes their participation in mechanism of immune inflammation and oxidative stress in this pathological process.I. D. BespalovаN. V. RyazantsevaV. V. KalyuzhinB. Yu. MurashevI. A. OsikhovY. A. MedyantsevD. S. Afanas’evaSPb RAACIarticlemetabolic syndromeinflammationmononuclear leukocytescd-markersreactive oxygen speciesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 345-352 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	metabolic syndrome inflammation mononuclear leukocytes cd-markers reactive oxygen species Immunologic diseases. Allergy RC581-607
spellingShingle	metabolic syndrome inflammation mononuclear leukocytes cd-markers reactive oxygen species Immunologic diseases. Allergy RC581-607 I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Y. A. Medyantsev D. S. Afanas’eva SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
description	Aim of study: to examine the features of expression of CD-markers of blood mononuclear leukocytes and their functional activity in the metabolic syndrome. Conducted a cross-sectional (transverse) study of 76 patients with essential hypertension (EH) II stage (BP <180/110 mm Hg.) [10] in conjunction with the metabolic syndrome and 20 people, formed the control group. Along with a complete clinical, laboratory and instrumental examination taken in a specialized cardiological clinic was conducted determination of surface markers of lymphocytes CD4+, CD8+ and monocytes CD36+ and assessment of the level of spontaneous production of reactive oxygen blood mononuclear leukocytes. Found that in patients with the metabolic syndrome compared with the control group the proportion of CD4+ lymphocytes and the level of spontaneous ROS production by mononuclear leukocytes significantly higher. The positive correlated interconnection between these indicators and the number of CD36+ monocytes with the majority of clinical and metabolic markers of MS confirmes their participation in mechanism of immune inflammation and oxidative stress in this pathological process.
format	article
author	I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Y. A. Medyantsev D. S. Afanas’eva
author_facet	I. D. Bespalovа N. V. Ryazantseva V. V. Kalyuzhin B. Yu. Murashev I. A. Osikhov Y. A. Medyantsev D. S. Afanas’eva
author_sort	I. D. Bespalovа
title	SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
title_short	SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
title_full	SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
title_fullStr	SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
title_full_unstemmed	SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME
title_sort	subpopulations and metabolic activity of blood mononuclear cells in metabolic syndrome
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/b1ed2388de0e40e0893f59f97fe2d658
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SUBPOPULATIONS AND METABOLIC ACTIVITY OF BLOOD MONONUCLEAR CELLS IN METABOLIC SYNDROME

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