Cellular Origin(s) of Congenital Diaphragmatic Hernia

Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial e...

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Auteurs principaux:	Gabriëla G. Edel, Gerben Schaaf, Rene M. H. Wijnen, Dick Tibboel, Gabrielle Kardon, Robbert J. Rottier
Format:	article
Langue:	EN
Publié:	Frontiers Media S.A. 2021
Sujets:	congenital diaphragmatic hernia (CDH) diaphragm pleuroperitoneal folds perivascular cells mesothelium Pediatrics RJ1-570
Accès en ligne:	https://doaj.org/article/b1ee41e42cc64e9f89c1c0499fc7b730
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spelling	oai:doaj.org-article:b1ee41e42cc64e9f89c1c0499fc7b7302021-12-01T18:34:06ZCellular Origin(s) of Congenital Diaphragmatic Hernia2296-236010.3389/fped.2021.804496https://doaj.org/article/b1ee41e42cc64e9f89c1c0499fc7b7302021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.804496/fullhttps://doaj.org/toc/2296-2360Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.Gabriëla G. EdelGabriëla G. EdelGerben SchaafGerben SchaafGerben SchaafRene M. H. WijnenDick TibboelGabrielle KardonRobbert J. RottierRobbert J. RottierFrontiers Media S.A.articlecongenital diaphragmatic hernia (CDH)diaphragmpleuroperitoneal foldsperivascular cellsmesotheliumPediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	congenital diaphragmatic hernia (CDH) diaphragm pleuroperitoneal folds perivascular cells mesothelium Pediatrics RJ1-570
spellingShingle	congenital diaphragmatic hernia (CDH) diaphragm pleuroperitoneal folds perivascular cells mesothelium Pediatrics RJ1-570 Gabriëla G. Edel Gabriëla G. Edel Gerben Schaaf Gerben Schaaf Gerben Schaaf Rene M. H. Wijnen Dick Tibboel Gabrielle Kardon Robbert J. Rottier Robbert J. Rottier Cellular Origin(s) of Congenital Diaphragmatic Hernia
description	Congenital diaphragmatic hernia (CDH) is a structural birth defect characterized by a diaphragmatic defect, lung hypoplasia and structural vascular defects. In spite of recent developments, the pathogenesis of CDH is still poorly understood. CDH is a complex congenital disorder with multifactorial etiology consisting of genetic, cellular and mechanical factors. This review explores the cellular origin of CDH pathogenesis in the diaphragm and lungs and describes recent developments in basic and translational CDH research.
format	article
author	Gabriëla G. Edel Gabriëla G. Edel Gerben Schaaf Gerben Schaaf Gerben Schaaf Rene M. H. Wijnen Dick Tibboel Gabrielle Kardon Robbert J. Rottier Robbert J. Rottier
author_facet	Gabriëla G. Edel Gabriëla G. Edel Gerben Schaaf Gerben Schaaf Gerben Schaaf Rene M. H. Wijnen Dick Tibboel Gabrielle Kardon Robbert J. Rottier Robbert J. Rottier
author_sort	Gabriëla G. Edel
title	Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_short	Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_full	Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_fullStr	Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_full_unstemmed	Cellular Origin(s) of Congenital Diaphragmatic Hernia
title_sort	cellular origin(s) of congenital diaphragmatic hernia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/b1ee41e42cc64e9f89c1c0499fc7b730
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Cellular Origin(s) of Congenital Diaphragmatic Hernia

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