Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice

Fashui Hong,1–4 Ling Wang5 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Huaiyin Normal University, Huaian, People’s Republic of China; 2Jiangsu Key Laboratory for Food Safety and Nutrition Function Evaluation, Huaiyin Norm...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hong F, Wang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Titanium dioxide nanoparticles Mice Premature ovarian failure Serum hormone levels Autoimmunity levels Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b1eebfb83d8f45ea87d222c736766a79
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b1eebfb83d8f45ea87d222c736766a79
record_format	dspace
spelling	oai:doaj.org-article:b1eebfb83d8f45ea87d222c736766a792021-12-02T07:23:56ZNanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice1178-2013https://doaj.org/article/b1eebfb83d8f45ea87d222c736766a792018-04-01T00:00:00Zhttps://www.dovepress.com/nanosized-titanium-dioxide-induced-premature-ovarian-failure-is-associ-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Fashui Hong,1–4 Ling Wang5 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Huaiyin Normal University, Huaian, People’s Republic of China; 2Jiangsu Key Laboratory for Food Safety and Nutrition Function Evaluation, Huaiyin Normal University, Huaian, People’s Republic of China; 3Jiangsu Key Laboratory for Eco-Agricultural Biotechnology Around Hongze Lake, Huaiyin Normal University, Huaian, People’s Republic of China; 4School of Life Sciences, Huaiyin Normal University, Huaian, People’s Republic of China; 5Library of Soochow University, Suzhou, People’s Republic of China Background: Exposure to titanium dioxide nanoparticles (TiO2 NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO2 NPs application on premature ovarian failure (POF) have rarely been evaluated to date. Methods: In this study, female mice were continuously exposed to TiO2 NPs at doses of 2.5, 5 or 10 mg/kg via gavage instillation for 30 days, and investigated the serum hormones and autoimmunity markers associated with POF. Results: Exposure to TiO2 NPs resulted in POF, reductions in the levels of estradiol, progesterone and inhibin B and increases in luteinizing hormone, follicle-stimulating hormone, follicle-stimulating hormone/luteinizing hormone ratio, anti-Müllerian hormone, thyroid-stimulating hormone, free triiodothyronine, free tetraiodothyronine, anti-nuclear antibody and anti-thyroid peroxidase antibody levels in serum. Conclusion: Exposure to TiO2 NPs induced POF triggered by alterations in hormones and autoimmunity markers. Our findings highlight the necessity for significant caution in handling and usage of TiO2 NPs by female consumers. Keywords: titanium dioxide nanoparticles, mice, premature ovarian failure, serum hormone levels, autoimmunity levelsHong FWang LDove Medical PressarticleTitanium dioxide nanoparticlesMicePremature ovarian failureSerum hormone levelsAutoimmunity levelsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2543-2549 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Titanium dioxide nanoparticles Mice Premature ovarian failure Serum hormone levels Autoimmunity levels Medicine (General) R5-920
spellingShingle	Titanium dioxide nanoparticles Mice Premature ovarian failure Serum hormone levels Autoimmunity levels Medicine (General) R5-920 Hong F Wang L Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
description	Fashui Hong,1–4 Ling Wang5 1Jiangsu Collaborative Innovation Center of Regional Modern Agriculture and Environmental Protection, Huaiyin Normal University, Huaian, People’s Republic of China; 2Jiangsu Key Laboratory for Food Safety and Nutrition Function Evaluation, Huaiyin Normal University, Huaian, People’s Republic of China; 3Jiangsu Key Laboratory for Eco-Agricultural Biotechnology Around Hongze Lake, Huaiyin Normal University, Huaian, People’s Republic of China; 4School of Life Sciences, Huaiyin Normal University, Huaian, People’s Republic of China; 5Library of Soochow University, Suzhou, People’s Republic of China Background: Exposure to titanium dioxide nanoparticles (TiO2 NPs) that are widely used in food, medicine, sunscreen products and cosmetics is reported to cause ovarian damage and lower fertility in animals. However, the potential effects of TiO2 NPs application on premature ovarian failure (POF) have rarely been evaluated to date. Methods: In this study, female mice were continuously exposed to TiO2 NPs at doses of 2.5, 5 or 10 mg/kg via gavage instillation for 30 days, and investigated the serum hormones and autoimmunity markers associated with POF. Results: Exposure to TiO2 NPs resulted in POF, reductions in the levels of estradiol, progesterone and inhibin B and increases in luteinizing hormone, follicle-stimulating hormone, follicle-stimulating hormone/luteinizing hormone ratio, anti-Müllerian hormone, thyroid-stimulating hormone, free triiodothyronine, free tetraiodothyronine, anti-nuclear antibody and anti-thyroid peroxidase antibody levels in serum. Conclusion: Exposure to TiO2 NPs induced POF triggered by alterations in hormones and autoimmunity markers. Our findings highlight the necessity for significant caution in handling and usage of TiO2 NPs by female consumers. Keywords: titanium dioxide nanoparticles, mice, premature ovarian failure, serum hormone levels, autoimmunity levels
format	article
author	Hong F Wang L
author_facet	Hong F Wang L
author_sort	Hong F
title	Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
title_short	Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
title_full	Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
title_fullStr	Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
title_full_unstemmed	Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
title_sort	nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/b1eebfb83d8f45ea87d222c736766a79
work_keys_str_mv	AT hongf nanosizedtitaniumdioxideinducedprematureovarianfailureisassociatedwithabnormalitiesinserumparametersinfemalemice AT wangl nanosizedtitaniumdioxideinducedprematureovarianfailureisassociatedwithabnormalitiesinserumparametersinfemalemice
_version_	1718399473410899968

Nanosized titanium dioxide-induced premature ovarian failure is associated with abnormalities in serum parameters in female mice

Ejemplares similares