The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

Abstract Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabete...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoo Jin Kim, Tae Gi Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1f30d80f5b44755981333488e84189b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b1f30d80f5b44755981333488e84189b
record_format	dspace
spelling	oai:doaj.org-article:b1f30d80f5b44755981333488e84189b2021-12-02T14:26:16ZThe effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness10.1038/s41598-021-87896-32045-2322https://doaj.org/article/b1f30d80f5b44755981333488e84189b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87896-3https://doaj.org/toc/2045-2322Abstract Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patients and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. For total ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥ 10 years) and high HbA1c (≥ 7%). When stratified by age group, from the 60 s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r = − 0.167; p = 0.000). These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients.Yoo Jin KimTae Gi KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoo Jin Kim Tae Gi Kim The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
description	Abstract Aim of this study is to evaluate the differences in corneal endothelial cell morphology and corneal thickness in patients with and without type 2 diabetes related to age, disease duration, and HbA1c percentage. This retrospective cross-sectional study included 511 (1022 eyes) type 2 diabetes patients and 900 (1799 eyes) non-diabetic patients. The endothelial cell density (ECD), variation in endothelial cell size (CV), percentage of hexagonal cells, and central corneal thickness (CCT) were analyzed using a noncontact specular microscope and a Pentacam Scheimpflug camera. We also examined the correlation between the corneal parameters and the duration of diabetes. For total ages, the subjects with type 2 diabetes showed significantly lower ECD, hexagonality, higher CV, and thicker CCT than the control group. This difference was more pronounced in patients with long-standing DM (≥ 10 years) and high HbA1c (≥ 7%). When stratified by age group, from the 60 s group, corneal endothelial cell parameters showed a statistically significant difference between DM and control groups. The duration of diabetes was inversely correlated with ECD (r = − 0.167; p = 0.000). These findings suggest that diabetes affects corneal endothelial cell in older age and those with long-standing DM and higher HbA1c. Regular corneal endothelial examinations are required in diabetic patients.
format	article
author	Yoo Jin Kim Tae Gi Kim
author_facet	Yoo Jin Kim Tae Gi Kim
author_sort	Yoo Jin Kim
title	The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
title_short	The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
title_full	The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
title_fullStr	The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
title_full_unstemmed	The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
title_sort	effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1f30d80f5b44755981333488e84189b
work_keys_str_mv	AT yoojinkim theeffectsoftype2diabetesmellitusonthecornealendotheliumandcentralcornealthickness AT taegikim theeffectsoftype2diabetesmellitusonthecornealendotheliumandcentralcornealthickness AT yoojinkim effectsoftype2diabetesmellitusonthecornealendotheliumandcentralcornealthickness AT taegikim effectsoftype2diabetesmellitusonthecornealendotheliumandcentralcornealthickness
_version_	1718391390069587968

The effects of type 2 diabetes mellitus on the corneal endothelium and central corneal thickness

Ejemplares similares