Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel

Abstract Ulcerative colitis is a chronic, idiopathic, and inflammatory disease of the rectal and colonic mucosa, the behavior of which is of heterogeneity in individuals. Here, we explored the multifactor-mediated functional modules associated with ulcerative colitis classification in the whole geno...

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Autores principales:	Lijie Lai, Hanyang Li, Qi Feng, Jun Shen, Zhihua Ran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1f37ca40b214c1897fa98c10aaf613b
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spelling	oai:doaj.org-article:b1f37ca40b214c1897fa98c10aaf613b2021-12-02T13:35:04ZMulti-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel10.1038/s41598-021-85000-32045-2322https://doaj.org/article/b1f37ca40b214c1897fa98c10aaf613b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85000-3https://doaj.org/toc/2045-2322Abstract Ulcerative colitis is a chronic, idiopathic, and inflammatory disease of the rectal and colonic mucosa, the behavior of which is of heterogeneity in individuals. Here, we explored the multifactor-mediated functional modules associated with ulcerative colitis classification in the whole genome. Datasets downloaded from the GEO database were used to identify differentially expressed genes between ulcerative colitis patients and healthy individuals initially, followed by acquisition of the remaining ulcerative colitis -related genes from the OMIM and STRING databases. The results identified 914 ulcerative colitis-related genes, of which 60 were differentially expressed genes obtained from GEO datasets. Through weighted co-expression network analysis of ulcerative colitis-related genes, four modules were obtained, three of which were related to ulcerative colitis. Following interactions between microRNA, long noncoding RNA, transcription factors, and module hub genes were predicted and used to construct ulcerative colitis multifactor networks. Additionally, we performed consensus clustering of the ulcerative colitis samples. The results revealed that ulcerative colitis could be divided into four subtypes, with six hub genes identified as potential biomarkers for classification. These findings offer novel insights into ulcerative colitis and a basis for disease classification of ulcerative colitis.Lijie LaiHanyang LiQi FengJun ShenZhihua RanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lijie Lai Hanyang Li Qi Feng Jun Shen Zhihua Ran Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
description	Abstract Ulcerative colitis is a chronic, idiopathic, and inflammatory disease of the rectal and colonic mucosa, the behavior of which is of heterogeneity in individuals. Here, we explored the multifactor-mediated functional modules associated with ulcerative colitis classification in the whole genome. Datasets downloaded from the GEO database were used to identify differentially expressed genes between ulcerative colitis patients and healthy individuals initially, followed by acquisition of the remaining ulcerative colitis -related genes from the OMIM and STRING databases. The results identified 914 ulcerative colitis-related genes, of which 60 were differentially expressed genes obtained from GEO datasets. Through weighted co-expression network analysis of ulcerative colitis-related genes, four modules were obtained, three of which were related to ulcerative colitis. Following interactions between microRNA, long noncoding RNA, transcription factors, and module hub genes were predicted and used to construct ulcerative colitis multifactor networks. Additionally, we performed consensus clustering of the ulcerative colitis samples. The results revealed that ulcerative colitis could be divided into four subtypes, with six hub genes identified as potential biomarkers for classification. These findings offer novel insights into ulcerative colitis and a basis for disease classification of ulcerative colitis.
format	article
author	Lijie Lai Hanyang Li Qi Feng Jun Shen Zhihua Ran
author_facet	Lijie Lai Hanyang Li Qi Feng Jun Shen Zhihua Ran
author_sort	Lijie Lai
title	Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
title_short	Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
title_full	Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
title_fullStr	Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
title_full_unstemmed	Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
title_sort	multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b1f37ca40b214c1897fa98c10aaf613b
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_version_	1718392693954969600

Multi-factor mediated functional modules identify novel classification of ulcerative colitis and functional gene panel

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