Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

Perilipin 5 has been implicated as a modulator of lipase activity and a scaffold linking lipid droplets to mitochondria. Here the authors show that PKA stimulates Peripilin 5 interaction with nuclear PGC-1a and SIRT1 to promote transcription of genes regulating mitochondrial biogenesis and respirati...

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Autores principales:	Violeta I. Gallardo-Montejano, Geetu Saxena, Christine M. Kusminski, Chaofeng Yang, John L. McAfee, Lisa Hahner, Kathleen Hoch, William Dubinsky, Vihang A. Narkar, Perry E. Bickel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b1f921515e444d0aba8b5eacf4781fb0
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spelling	oai:doaj.org-article:b1f921515e444d0aba8b5eacf4781fb02021-12-02T16:58:11ZNuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function10.1038/ncomms127232041-1723https://doaj.org/article/b1f921515e444d0aba8b5eacf4781fb02016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12723https://doaj.org/toc/2041-1723Perilipin 5 has been implicated as a modulator of lipase activity and a scaffold linking lipid droplets to mitochondria. Here the authors show that PKA stimulates Peripilin 5 interaction with nuclear PGC-1a and SIRT1 to promote transcription of genes regulating mitochondrial biogenesis and respiration.Violeta I. Gallardo-MontejanoGeetu SaxenaChristine M. KusminskiChaofeng YangJohn L. McAfeeLisa HahnerKathleen HochWilliam DubinskyVihang A. NarkarPerry E. BickelNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Violeta I. Gallardo-Montejano Geetu Saxena Christine M. Kusminski Chaofeng Yang John L. McAfee Lisa Hahner Kathleen Hoch William Dubinsky Vihang A. Narkar Perry E. Bickel Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
description	Perilipin 5 has been implicated as a modulator of lipase activity and a scaffold linking lipid droplets to mitochondria. Here the authors show that PKA stimulates Peripilin 5 interaction with nuclear PGC-1a and SIRT1 to promote transcription of genes regulating mitochondrial biogenesis and respiration.
format	article
author	Violeta I. Gallardo-Montejano Geetu Saxena Christine M. Kusminski Chaofeng Yang John L. McAfee Lisa Hahner Kathleen Hoch William Dubinsky Vihang A. Narkar Perry E. Bickel
author_facet	Violeta I. Gallardo-Montejano Geetu Saxena Christine M. Kusminski Chaofeng Yang John L. McAfee Lisa Hahner Kathleen Hoch William Dubinsky Vihang A. Narkar Perry E. Bickel
author_sort	Violeta I. Gallardo-Montejano
title	Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
title_short	Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
title_full	Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
title_fullStr	Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
title_full_unstemmed	Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function
title_sort	nuclear perilipin 5 integrates lipid droplet lipolysis with pgc-1α/sirt1-dependent transcriptional regulation of mitochondrial function
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/b1f921515e444d0aba8b5eacf4781fb0
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Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1α/SIRT1-dependent transcriptional regulation of mitochondrial function

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