Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy

Abstract Left ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occur...

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Autores principales:	Paolo Piras, Concetta Torromeo, Antonietta Evangelista, Stefano Gabriele, Giuseppe Esposito, Paola Nardinocchi, Luciano Teresi, Andrea Madeo, Michele Schiariti, Valerio Varano, Paolo Emilio Puddu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b1f923f13c0e405ba79f2be7cd578e4e
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spelling	oai:doaj.org-article:b1f923f13c0e405ba79f2be7cd578e4e2021-12-02T16:08:19ZHomeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy10.1038/s41598-017-06189-w2045-2322https://doaj.org/article/b1f923f13c0e405ba79f2be7cd578e4e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06189-whttps://doaj.org/toc/2045-2322Abstract Left ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring in systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness about the entire left ventricle or left atrium revolution and on their deficiencies that take place in presence of hypertrophic cardiomyopathy. However, surprisingly, the concomitant function of the two left heart chambers has not been analyzed for their geometrical/mechanical relationship. For the first time we study here, by acquiring left ventricle and left atrial geometries on the same heartbeat, the trajectory attributes of the entire left heart treated as a whole shape and the shape covariation of its two subunits. We contrasted healthy subjects with patients affected by hypertrophic cardiomyopathy. We found impaired left heart trajectory mainly in terms of orientation and size. More importantly, we found profound differences in the direction of morphological covariation of left ventricle and left atrium. These findings open to new perspectives in pathophysiological evaluation of different diseases by allowing the appreciation of concomitant functioning of both left heart whole geometry and of its two chambers.Paolo PirasConcetta TorromeoAntonietta EvangelistaStefano GabrieleGiuseppe EspositoPaola NardinocchiLuciano TeresiAndrea MadeoMichele SchiaritiValerio VaranoPaolo Emilio PudduNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Paolo Piras Concetta Torromeo Antonietta Evangelista Stefano Gabriele Giuseppe Esposito Paola Nardinocchi Luciano Teresi Andrea Madeo Michele Schiariti Valerio Varano Paolo Emilio Puddu Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
description	Abstract Left ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring in systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness about the entire left ventricle or left atrium revolution and on their deficiencies that take place in presence of hypertrophic cardiomyopathy. However, surprisingly, the concomitant function of the two left heart chambers has not been analyzed for their geometrical/mechanical relationship. For the first time we study here, by acquiring left ventricle and left atrial geometries on the same heartbeat, the trajectory attributes of the entire left heart treated as a whole shape and the shape covariation of its two subunits. We contrasted healthy subjects with patients affected by hypertrophic cardiomyopathy. We found impaired left heart trajectory mainly in terms of orientation and size. More importantly, we found profound differences in the direction of morphological covariation of left ventricle and left atrium. These findings open to new perspectives in pathophysiological evaluation of different diseases by allowing the appreciation of concomitant functioning of both left heart whole geometry and of its two chambers.
format	article
author	Paolo Piras Concetta Torromeo Antonietta Evangelista Stefano Gabriele Giuseppe Esposito Paola Nardinocchi Luciano Teresi Andrea Madeo Michele Schiariti Valerio Varano Paolo Emilio Puddu
author_facet	Paolo Piras Concetta Torromeo Antonietta Evangelista Stefano Gabriele Giuseppe Esposito Paola Nardinocchi Luciano Teresi Andrea Madeo Michele Schiariti Valerio Varano Paolo Emilio Puddu
author_sort	Paolo Piras
title	Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
title_short	Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
title_full	Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
title_fullStr	Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
title_full_unstemmed	Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy
title_sort	homeostatic left heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in hypertrophic cardiomyopathy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b1f923f13c0e405ba79f2be7cd578e4e
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Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy

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