Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of d...
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Endocrinology Research Centre
2017
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oai:doaj.org-article:b1f9249749b340b49953fd5e2ba62b722021-11-14T09:00:21ZPredictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus2072-03512072-037810.14341/8156https://doaj.org/article/b1f9249749b340b49953fd5e2ba62b722017-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8232https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of diabetes; however, it is often underestimated and not recognised by practitioners. Medical history and a physical examination are not sufficient for diagnosing DCAN. Laboratory diagnosis and the instrumental methods used to evaluate DCAN are time-consuming and not always available. Early detection of DCAN in diabetic patients is important for the early implementation of therapy. Today, there is no uniform diagnostic algorithm for DCAN in patients with various disorders of carbohydrate metabolism. This is due to the insufficient number of clinical trials and limitations of current protocols. This review presents an overview of the clinical and experimental studies of DCAN. The epidemiology, clinical manifestations, risk factors and underlying pathogenesis of DCAN are considered. The advantages and disadvantages of conventional and new diagnostic methods are discussed.Kirill A. PopovAlla Y. TokmakovaIrina Z. BondarenkoEndocrinology Research Centrearticlediabetesdiabetic cardiovascular autonomic neuropathyheart rate variabilitycardiovascular magnetic resonanceradionuclide imagingNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 3, Pp 185-193 (2017) |
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diabetes diabetic cardiovascular autonomic neuropathy heart rate variability cardiovascular magnetic resonance radionuclide imaging Nutritional diseases. Deficiency diseases RC620-627 |
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diabetes diabetic cardiovascular autonomic neuropathy heart rate variability cardiovascular magnetic resonance radionuclide imaging Nutritional diseases. Deficiency diseases RC620-627 Kirill A. Popov Alla Y. Tokmakova Irina Z. Bondarenko Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
description |
Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of diabetes; however, it is often underestimated and not recognised by practitioners. Medical history and a physical examination are not sufficient for diagnosing DCAN. Laboratory diagnosis and the instrumental methods used to evaluate DCAN are time-consuming and not always available. Early detection of DCAN in diabetic patients is important for the early implementation of therapy. Today, there is no uniform diagnostic algorithm for DCAN in patients with various disorders of carbohydrate metabolism. This is due to the insufficient number of clinical trials and limitations of current protocols.
This review presents an overview of the clinical and experimental studies of DCAN. The epidemiology, clinical manifestations, risk factors and underlying pathogenesis of DCAN are considered. The advantages and disadvantages of conventional and new diagnostic methods are discussed. |
format |
article |
author |
Kirill A. Popov Alla Y. Tokmakova Irina Z. Bondarenko |
author_facet |
Kirill A. Popov Alla Y. Tokmakova Irina Z. Bondarenko |
author_sort |
Kirill A. Popov |
title |
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
title_short |
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
title_full |
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
title_fullStr |
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
title_full_unstemmed |
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
title_sort |
predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus |
publisher |
Endocrinology Research Centre |
publishDate |
2017 |
url |
https://doaj.org/article/b1f9249749b340b49953fd5e2ba62b72 |
work_keys_str_mv |
AT kirillapopov predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus AT allaytokmakova predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus AT irinazbondarenko predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus |
_version_ |
1718429550919024640 |