Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus

Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of d...

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Autores principales: Kirill A. Popov, Alla Y. Tokmakova, Irina Z. Bondarenko
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RU
Publicado: Endocrinology Research Centre 2017
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spelling oai:doaj.org-article:b1f9249749b340b49953fd5e2ba62b722021-11-14T09:00:21ZPredictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus2072-03512072-037810.14341/8156https://doaj.org/article/b1f9249749b340b49953fd5e2ba62b722017-08-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/8232https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of diabetes; however, it is often underestimated and not recognised by practitioners. Medical history and a physical examination are not sufficient for diagnosing DCAN. Laboratory diagnosis and the instrumental methods used to evaluate DCAN are time-consuming and not always available. Early detection of DCAN in diabetic patients is important for the early implementation of therapy. Today, there is no uniform diagnostic algorithm for DCAN in patients with various disorders of carbohydrate metabolism. This is due to the insufficient number of clinical trials and limitations of current protocols. This review presents an overview of the clinical and experimental studies of DCAN. The epidemiology, clinical manifestations, risk factors and underlying pathogenesis of DCAN are considered. The advantages and disadvantages of conventional and new diagnostic methods are discussed.Kirill A. PopovAlla Y. TokmakovaIrina Z. BondarenkoEndocrinology Research Centrearticlediabetesdiabetic cardiovascular autonomic neuropathyheart rate variabilitycardiovascular magnetic resonanceradionuclide imagingNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 20, Iss 3, Pp 185-193 (2017)
institution DOAJ
collection DOAJ
language EN
RU
topic diabetes
diabetic cardiovascular autonomic neuropathy
heart rate variability
cardiovascular magnetic resonance
radionuclide imaging
Nutritional diseases. Deficiency diseases
RC620-627
spellingShingle diabetes
diabetic cardiovascular autonomic neuropathy
heart rate variability
cardiovascular magnetic resonance
radionuclide imaging
Nutritional diseases. Deficiency diseases
RC620-627
Kirill A. Popov
Alla Y. Tokmakova
Irina Z. Bondarenko
Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
description Diabetic cardiovascular autonomic neuropathy (DCAN) is a diabetic complication characterised by early dissemination of sympathetic and parasympathetic, small-fibre neuronal degeneration. DCAN is the most dangerous and insidious complication that influences the clinical course and mortality rate of diabetes; however, it is often underestimated and not recognised by practitioners. Medical history and a physical examination are not sufficient for diagnosing DCAN. Laboratory diagnosis and the instrumental methods used to evaluate DCAN are time-consuming and not always available. Early detection of DCAN in diabetic patients is important for the early implementation of therapy. Today, there is no uniform diagnostic algorithm for DCAN in patients with various disorders of carbohydrate metabolism. This is due to the insufficient number of clinical trials and limitations of current protocols. This review presents an overview of the clinical and experimental studies of DCAN. The epidemiology, clinical manifestations, risk factors and underlying pathogenesis of DCAN are considered. The advantages and disadvantages of conventional and new diagnostic methods are discussed.
format article
author Kirill A. Popov
Alla Y. Tokmakova
Irina Z. Bondarenko
author_facet Kirill A. Popov
Alla Y. Tokmakova
Irina Z. Bondarenko
author_sort Kirill A. Popov
title Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
title_short Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
title_full Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
title_fullStr Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
title_full_unstemmed Predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
title_sort predictors and diagnosis of cardiac autonomic nervous dysfunction in patients with type 1 and type 2 diabetes mellitus
publisher Endocrinology Research Centre
publishDate 2017
url https://doaj.org/article/b1f9249749b340b49953fd5e2ba62b72
work_keys_str_mv AT kirillapopov predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus
AT allaytokmakova predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus
AT irinazbondarenko predictorsanddiagnosisofcardiacautonomicnervousdysfunctioninpatientswithtype1andtype2diabetesmellitus
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