Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

Studies of neural dynamics in lateral orbitofrontal cortex (lOFC) have shown that subsets of neurons that encode distinct aspects of behavior, such as value, may project to common downstream targets. However, it is unclear whether reward history, which may subserve lOFC’s well-documented role in lea...

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Autores principales:	David L Hocker, Carlos D Brody, Cristina Savin, Christine M Constantinople
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	orbitofrontal cortex decision-making sequential bias clustering generalized linear model learning Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/b1fd5776733d4c0286576c239586eb0e
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spelling	oai:doaj.org-article:b1fd5776733d4c0286576c239586eb0e2021-11-25T09:13:59ZSubpopulations of neurons in lOFC encode previous and current rewards at time of choice10.7554/eLife.701292050-084Xe70129https://doaj.org/article/b1fd5776733d4c0286576c239586eb0e2021-10-01T00:00:00Zhttps://elifesciences.org/articles/70129https://doaj.org/toc/2050-084XStudies of neural dynamics in lateral orbitofrontal cortex (lOFC) have shown that subsets of neurons that encode distinct aspects of behavior, such as value, may project to common downstream targets. However, it is unclear whether reward history, which may subserve lOFC’s well-documented role in learning, is represented by functional subpopulations in lOFC. Previously, we analyzed neural recordings from rats performing a value-based decision-making task, and we documented trial-by-trial learning that required lOFC (Constantinople et al., 2019). Here, we characterize functional subpopulations of lOFC neurons during behavior, including their encoding of task variables. We found five distinct clusters of lOFC neurons, either based on clustering of their trial-averaged peristimulus time histograms (PSTHs), or a feature space defined by their average conditional firing rates aligned to different task variables. We observed weak encoding of reward attributes, but stronger encoding of reward history, the animal’s left or right choice, and reward receipt across all clusters. Only one cluster, however, encoded the animal’s reward history at the time shortly preceding the choice, suggesting a possible role in integrating previous and current trial outcomes at the time of choice. This cluster also exhibits qualitatively similar responses to identified corticostriatal projection neurons in a recent study (Hirokawa et al., 2019), and suggests a possible role for subpopulations of lOFC neurons in mediating trial-by-trial learning.David L HockerCarlos D BrodyCristina SavinChristine M ConstantinopleeLife Sciences Publications Ltdarticleorbitofrontal cortexdecision-makingsequential biasclusteringgeneralized linear modellearningMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	orbitofrontal cortex decision-making sequential bias clustering generalized linear model learning Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	orbitofrontal cortex decision-making sequential bias clustering generalized linear model learning Medicine R Science Q Biology (General) QH301-705.5 David L Hocker Carlos D Brody Cristina Savin Christine M Constantinople Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
description	Studies of neural dynamics in lateral orbitofrontal cortex (lOFC) have shown that subsets of neurons that encode distinct aspects of behavior, such as value, may project to common downstream targets. However, it is unclear whether reward history, which may subserve lOFC’s well-documented role in learning, is represented by functional subpopulations in lOFC. Previously, we analyzed neural recordings from rats performing a value-based decision-making task, and we documented trial-by-trial learning that required lOFC (Constantinople et al., 2019). Here, we characterize functional subpopulations of lOFC neurons during behavior, including their encoding of task variables. We found five distinct clusters of lOFC neurons, either based on clustering of their trial-averaged peristimulus time histograms (PSTHs), or a feature space defined by their average conditional firing rates aligned to different task variables. We observed weak encoding of reward attributes, but stronger encoding of reward history, the animal’s left or right choice, and reward receipt across all clusters. Only one cluster, however, encoded the animal’s reward history at the time shortly preceding the choice, suggesting a possible role in integrating previous and current trial outcomes at the time of choice. This cluster also exhibits qualitatively similar responses to identified corticostriatal projection neurons in a recent study (Hirokawa et al., 2019), and suggests a possible role for subpopulations of lOFC neurons in mediating trial-by-trial learning.
format	article
author	David L Hocker Carlos D Brody Cristina Savin Christine M Constantinople
author_facet	David L Hocker Carlos D Brody Cristina Savin Christine M Constantinople
author_sort	David L Hocker
title	Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
title_short	Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
title_full	Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
title_fullStr	Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
title_full_unstemmed	Subpopulations of neurons in lOFC encode previous and current rewards at time of choice
title_sort	subpopulations of neurons in lofc encode previous and current rewards at time of choice
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/b1fd5776733d4c0286576c239586eb0e
work_keys_str_mv	AT davidlhocker subpopulationsofneuronsinlofcencodepreviousandcurrentrewardsattimeofchoice AT carlosdbrody subpopulationsofneuronsinlofcencodepreviousandcurrentrewardsattimeofchoice AT cristinasavin subpopulationsofneuronsinlofcencodepreviousandcurrentrewardsattimeofchoice AT christinemconstantinople subpopulationsofneuronsinlofcencodepreviousandcurrentrewardsattimeofchoice
_version_	1718413579795824640

Subpopulations of neurons in lOFC encode previous and current rewards at time of choice

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