Influenza Viruses and mRNA Splicing: Doing More with Less

ABSTRACT During their nuclear replication stage, influenza viruses hijack the host splicing machinery to process some of their RNA segments, the M and NS segments. In this review, we provide an overview of the current knowledge gathered on this interplay between influenza viruses and the cellular sp...

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Autores principales:	Julia Dubois, Olivier Terrier, Manuel Rosa-Calatrava
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2014
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/b1fdef7c9f004d33a55ff89d4fc573b8
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spelling	oai:doaj.org-article:b1fdef7c9f004d33a55ff89d4fc573b82021-11-15T15:47:39ZInfluenza Viruses and mRNA Splicing: Doing More with Less10.1128/mBio.00070-142150-7511https://doaj.org/article/b1fdef7c9f004d33a55ff89d4fc573b82014-07-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00070-14https://doaj.org/toc/2150-7511ABSTRACT During their nuclear replication stage, influenza viruses hijack the host splicing machinery to process some of their RNA segments, the M and NS segments. In this review, we provide an overview of the current knowledge gathered on this interplay between influenza viruses and the cellular spliceosome, with a particular focus on influenza A viruses (IAV). These viruses have developed accurate regulation mechanisms to reassign the host spliceosome to alter host cellular expression and enable an optimal expression of specific spliced viral products throughout infection. Moreover, IAV segments undergoing splicing display high levels of similarity with human consensus splice sites and their viral transcripts show noteworthy secondary structures. Sequence alignments and consensus analyses, along with recently published studies, suggest both conservation and evolution of viral splice site sequences and structure for improved adaptation to the host. Altogether, these results emphasize the ability of IAV to be well adapted to the host’s splicing machinery, and further investigations may contribute to a better understanding of splicing regulation with regard to viral replication, host range, and pathogenesis.Julia DuboisOlivier TerrierManuel Rosa-CalatravaAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 5, Iss 3 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Julia Dubois Olivier Terrier Manuel Rosa-Calatrava Influenza Viruses and mRNA Splicing: Doing More with Less
description	ABSTRACT During their nuclear replication stage, influenza viruses hijack the host splicing machinery to process some of their RNA segments, the M and NS segments. In this review, we provide an overview of the current knowledge gathered on this interplay between influenza viruses and the cellular spliceosome, with a particular focus on influenza A viruses (IAV). These viruses have developed accurate regulation mechanisms to reassign the host spliceosome to alter host cellular expression and enable an optimal expression of specific spliced viral products throughout infection. Moreover, IAV segments undergoing splicing display high levels of similarity with human consensus splice sites and their viral transcripts show noteworthy secondary structures. Sequence alignments and consensus analyses, along with recently published studies, suggest both conservation and evolution of viral splice site sequences and structure for improved adaptation to the host. Altogether, these results emphasize the ability of IAV to be well adapted to the host’s splicing machinery, and further investigations may contribute to a better understanding of splicing regulation with regard to viral replication, host range, and pathogenesis.
format	article
author	Julia Dubois Olivier Terrier Manuel Rosa-Calatrava
author_facet	Julia Dubois Olivier Terrier Manuel Rosa-Calatrava
author_sort	Julia Dubois
title	Influenza Viruses and mRNA Splicing: Doing More with Less
title_short	Influenza Viruses and mRNA Splicing: Doing More with Less
title_full	Influenza Viruses and mRNA Splicing: Doing More with Less
title_fullStr	Influenza Viruses and mRNA Splicing: Doing More with Less
title_full_unstemmed	Influenza Viruses and mRNA Splicing: Doing More with Less
title_sort	influenza viruses and mrna splicing: doing more with less
publisher	American Society for Microbiology
publishDate	2014
url	https://doaj.org/article/b1fdef7c9f004d33a55ff89d4fc573b8
work_keys_str_mv	AT juliadubois influenzavirusesandmrnasplicingdoingmorewithless AT olivierterrier influenzavirusesandmrnasplicingdoingmorewithless AT manuelrosacalatrava influenzavirusesandmrnasplicingdoingmorewithless
_version_	1718427540377305088

Influenza Viruses and mRNA Splicing: Doing More with Less

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