Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition...

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Autores principales:	Giulia Agliardi, Anna Rita Liuzzi, Alastair Hotblack, Donatella De Feo, Nicolás Núñez, Cassandra L. Stowe, Ekaterina Friebel, Francesco Nannini, Lukas Rindlisbacher, Thomas A. Roberts, Rajiv Ramasawmy, Iwan P. Williams, Bernard M. Siow, Mark F. Lythgoe, Tammy L. Kalber, Sergio A. Quezada, Martin A. Pule, Sonia Tugues, Karin Straathof, Burkhard Becher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b2005a4f42464b199597399076f130a8
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spelling	oai:doaj.org-article:b2005a4f42464b199597399076f130a82021-12-02T14:18:54ZIntratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma10.1038/s41467-020-20599-x2041-1723https://doaj.org/article/b2005a4f42464b199597399076f130a82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20599-xhttps://doaj.org/toc/2041-1723Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition the microenvironment and promote anti-tumor immunity.Giulia AgliardiAnna Rita LiuzziAlastair HotblackDonatella De FeoNicolás NúñezCassandra L. StoweEkaterina FriebelFrancesco NanniniLukas RindlisbacherThomas A. RobertsRajiv RamasawmyIwan P. WilliamsBernard M. SiowMark F. LythgoeTammy L. KalberSergio A. QuezadaMartin A. PuleSonia TuguesKarin StraathofBurkhard BecherNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giulia Agliardi Anna Rita Liuzzi Alastair Hotblack Donatella De Feo Nicolás Núñez Cassandra L. Stowe Ekaterina Friebel Francesco Nannini Lukas Rindlisbacher Thomas A. Roberts Rajiv Ramasawmy Iwan P. Williams Bernard M. Siow Mark F. Lythgoe Tammy L. Kalber Sergio A. Quezada Martin A. Pule Sonia Tugues Karin Straathof Burkhard Becher Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
description	Glioblastoma multiform (GBM) is a common and aggressive type of primary brain cancer that currently has no effective therapy. Here, the authors show, using a mouse GBM model and EGFRvIII-targeting chimeric antigen receptor (CAR)-T cells, that Intratumoral injection of interleukin-12 helps condition the microenvironment and promote anti-tumor immunity.
format	article
author	Giulia Agliardi Anna Rita Liuzzi Alastair Hotblack Donatella De Feo Nicolás Núñez Cassandra L. Stowe Ekaterina Friebel Francesco Nannini Lukas Rindlisbacher Thomas A. Roberts Rajiv Ramasawmy Iwan P. Williams Bernard M. Siow Mark F. Lythgoe Tammy L. Kalber Sergio A. Quezada Martin A. Pule Sonia Tugues Karin Straathof Burkhard Becher
author_facet	Giulia Agliardi Anna Rita Liuzzi Alastair Hotblack Donatella De Feo Nicolás Núñez Cassandra L. Stowe Ekaterina Friebel Francesco Nannini Lukas Rindlisbacher Thomas A. Roberts Rajiv Ramasawmy Iwan P. Williams Bernard M. Siow Mark F. Lythgoe Tammy L. Kalber Sergio A. Quezada Martin A. Pule Sonia Tugues Karin Straathof Burkhard Becher
author_sort	Giulia Agliardi
title	Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
title_short	Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
title_full	Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
title_fullStr	Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
title_full_unstemmed	Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma
title_sort	intratumoral il-12 delivery empowers car-t cell immunotherapy in a pre-clinical model of glioblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b2005a4f42464b199597399076f130a8
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Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

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