Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders
Vanessa Blas-Valdivia, Edgar Cano-Europa, Adelaida Hernández-García, Rocio Ortiz-ButrónDepartamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y...
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Dove Medical Press
2008
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oai:doaj.org-article:b201593291454984bd1edd42aa9248ab2021-12-02T06:17:10ZNeonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders1176-63281178-2021https://doaj.org/article/b201593291454984bd1edd42aa9248ab2008-12-01T00:00:00Zhttp://www.dovepress.com/neonatal-bilateral-lidocaine-administration-into-the-ventral-hippocamp-a2660https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Vanessa Blas-Valdivia, Edgar Cano-Europa, Adelaida Hernández-García, Rocio Ortiz-ButrónDepartamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y Plan de Ayala, MéxicoAbstract: Our aim was to investigate if neonatal bilateral administration of lidocaine into the ventral hippocampus would cause behavioral changes related to schizophrenia. A neonatal ventral-hippocampal lesion (nVH lesion) was made with lidocaine in Wistar male pups. Two groups were formed, the first received lidocaine (4 μg/0.3 μL) and the second an equal volume of vehicle. At day 35 and 56, both groups were tested for social contact, immobility caused by clamping the neck and dorsal immobility, locomotor activity in an open field, and tail flick (TF) latency after a painful heat stimulus. All animals were then killed. Coronal cuts (7 μm) of the brain were obtained and each brain section was stained with cresyl violet-eosin. The animals which received the nVH lesion with lidocaine had decreased social interaction at both ages. The rats with lesions, only at day 58 postnatal, increased their distance traveled and ambulatory time, with a decrease in their nonambulatory and reset time. The rats with lesions had a longer duration of immobility caused by clamping the neck and a longer dorsal immobility at both days 34 and 57 compared to control rats. The lidocaine-treated group spent less time to deflect the tail compared to the control group at postpubertal age. The neonatal bilateral administration of lidocaine into the ventral hippocampus caused some alterations, such as chromatin condensation, nucleolus loss, and cell shrinkage, but glial proliferation was not seen. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes.Keywords: lidocaine, hippocampus, neonatal lesion, behavior, animal model, psychopathological disorders Vanessa Blas-ValdiviaEdgar Cano-EuropaAdelaida Hernández-GarcíaRocio Ortiz-ButrónDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 15-22 (2008) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Vanessa Blas-Valdivia Edgar Cano-Europa Adelaida Hernández-García Rocio Ortiz-Butrón Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| description |
Vanessa Blas-Valdivia, Edgar Cano-Europa, Adelaida Hernández-García, Rocio Ortiz-ButrónDepartamento de Fisiología “Mauricio Russek Berman”, Escuela Nacional de Ciencias Biológicas, I.P.N., Carpio y Plan de Ayala, MéxicoAbstract: Our aim was to investigate if neonatal bilateral administration of lidocaine into the ventral hippocampus would cause behavioral changes related to schizophrenia. A neonatal ventral-hippocampal lesion (nVH lesion) was made with lidocaine in Wistar male pups. Two groups were formed, the first received lidocaine (4 μg/0.3 μL) and the second an equal volume of vehicle. At day 35 and 56, both groups were tested for social contact, immobility caused by clamping the neck and dorsal immobility, locomotor activity in an open field, and tail flick (TF) latency after a painful heat stimulus. All animals were then killed. Coronal cuts (7 μm) of the brain were obtained and each brain section was stained with cresyl violet-eosin. The animals which received the nVH lesion with lidocaine had decreased social interaction at both ages. The rats with lesions, only at day 58 postnatal, increased their distance traveled and ambulatory time, with a decrease in their nonambulatory and reset time. The rats with lesions had a longer duration of immobility caused by clamping the neck and a longer dorsal immobility at both days 34 and 57 compared to control rats. The lidocaine-treated group spent less time to deflect the tail compared to the control group at postpubertal age. The neonatal bilateral administration of lidocaine into the ventral hippocampus caused some alterations, such as chromatin condensation, nucleolus loss, and cell shrinkage, but glial proliferation was not seen. Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes.Keywords: lidocaine, hippocampus, neonatal lesion, behavior, animal model, psychopathological disorders |
| format |
article |
| author |
Vanessa Blas-Valdivia Edgar Cano-Europa Adelaida Hernández-García Rocio Ortiz-Butrón |
| author_facet |
Vanessa Blas-Valdivia Edgar Cano-Europa Adelaida Hernández-García Rocio Ortiz-Butrón |
| author_sort |
Vanessa Blas-Valdivia |
| title |
Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| title_short |
Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| title_full |
Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| title_fullStr |
Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| title_full_unstemmed |
Neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: An animal model of neurodevelopmental psychopathological disorders |
| title_sort |
neonatal bilateral lidocaine administration into the ventral hippocampus caused postpubertal behavioral changes: an animal model of neurodevelopmental psychopathological disorders |
| publisher |
Dove Medical Press |
| publishDate |
2008 |
| url |
https://doaj.org/article/b201593291454984bd1edd42aa9248ab |
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