Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress
Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.
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Nature Portfolio
2021
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oai:doaj.org-article:b20321b21d3a4a83a7ef31a0fb9d941a2021-12-02T14:18:55ZFetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress10.1038/s41467-020-20832-72041-1723https://doaj.org/article/b20321b21d3a4a83a7ef31a0fb9d941a2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20832-7https://doaj.org/toc/2041-1723Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis.Stefan RudloffMathilde JanotStephane RodriguezKevin DessalleWilli Jahnen-DechentUyen Huynh-DoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
description |
Intrauterine growth restriction is associated with increased risk for chronic diseases in adults. Here the authors identify fetuin-A as a HIF target gene and describe its protective role in the kidney, counteracting disease mechanisms such as calcification, macrophage polarization, and fibrosis. |
format |
article |
author |
Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do |
author_facet |
Stefan Rudloff Mathilde Janot Stephane Rodriguez Kevin Dessalle Willi Jahnen-Dechent Uyen Huynh-Do |
author_sort |
Stefan Rudloff |
title |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
title_short |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
title_full |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
title_fullStr |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
title_full_unstemmed |
Fetuin-A is a HIF target that safeguards tissue integrity during hypoxic stress |
title_sort |
fetuin-a is a hif target that safeguards tissue integrity during hypoxic stress |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/b20321b21d3a4a83a7ef31a0fb9d941a |
work_keys_str_mv |
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1718391627660132352 |