Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV.
<h4>Background and aims</h4>Several studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage of uncertain origin (LDUO). The objective of our study was to evaluate the incidence of and risk factors for the development of LDUO in HI...
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oai:doaj.org-article:b204072b79b4432392831e20a0c0ecc82021-11-18T07:37:15ZIncidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV.1932-620310.1371/journal.pone.0068953https://doaj.org/article/b204072b79b4432392831e20a0c0ecc82013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874824/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and aims</h4>Several studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage of uncertain origin (LDUO). The objective of our study was to evaluate the incidence of and risk factors for the development of LDUO in HIV infected patients not co-infected with HCV/HBV.<h4>Methods</h4>Prospective longitudinal study that included HIV-infected patients free of previous liver damage and viral hepatitis B or C co-infections. Patients were followed up at 6-monthly intervals. Liver stiffness was measured at each visit. Abnormal liver stiffness (ALS) was defined as a liver stiffness value greater than 7.2 kPa at two consecutive measurements. For patients who developed ALS, a protocol was followed to diagnose the cause of liver damage. Those patients who could not be diagnosed with any specific cause of liver disease were diagnosed as LDUO and liver biopsy was proposed.<h4>Results</h4>210 patients matched the inclusion criteria and were included. 198 patients completed the study. After a median (Q1-Q3) follow-up of 18 (IQR 12-26) months, 21 patients (10.6%) developed ALS. Of these, fifteen patients were diagnosed as LDUO. The incidence of LDUO was 7.64 cases/100 patient-years. Histological studies were performed on ten (66.6%) patients and all showed liver steatosis. A higher HOMA-IR value and body mass index were independently associated with the development of LDUO.<h4>Conclusion</h4>We found a high incidence of LDUO in HIV-infected patients associated with metabolic risk factors. The leading cause of LDUO in our study was non-alcoholic fatty liver disease.Antonio Rivero-JuárezAngela CamachoNicolás MerchanteInés Pérez-CamachoJuan MaciasCarmen Ortiz-GarciaCelia CifuentesJulián Torre-CisnerosJosé PeñaJuan A PinedaAntonio RiveroGrupo para el estudio de las hepatitis vı´ricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI)Public Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68953 (2013) |
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Medicine R Science Q Antonio Rivero-Juárez Angela Camacho Nicolás Merchante Inés Pérez-Camacho Juan Macias Carmen Ortiz-Garcia Celia Cifuentes Julián Torre-Cisneros José Peña Juan A Pineda Antonio Rivero Grupo para el estudio de las hepatitis vı´ricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI) Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| description |
<h4>Background and aims</h4>Several studies have reported that a significant number of HIV patients not co-infected with HCV/HBV develop liver damage of uncertain origin (LDUO). The objective of our study was to evaluate the incidence of and risk factors for the development of LDUO in HIV infected patients not co-infected with HCV/HBV.<h4>Methods</h4>Prospective longitudinal study that included HIV-infected patients free of previous liver damage and viral hepatitis B or C co-infections. Patients were followed up at 6-monthly intervals. Liver stiffness was measured at each visit. Abnormal liver stiffness (ALS) was defined as a liver stiffness value greater than 7.2 kPa at two consecutive measurements. For patients who developed ALS, a protocol was followed to diagnose the cause of liver damage. Those patients who could not be diagnosed with any specific cause of liver disease were diagnosed as LDUO and liver biopsy was proposed.<h4>Results</h4>210 patients matched the inclusion criteria and were included. 198 patients completed the study. After a median (Q1-Q3) follow-up of 18 (IQR 12-26) months, 21 patients (10.6%) developed ALS. Of these, fifteen patients were diagnosed as LDUO. The incidence of LDUO was 7.64 cases/100 patient-years. Histological studies were performed on ten (66.6%) patients and all showed liver steatosis. A higher HOMA-IR value and body mass index were independently associated with the development of LDUO.<h4>Conclusion</h4>We found a high incidence of LDUO in HIV-infected patients associated with metabolic risk factors. The leading cause of LDUO in our study was non-alcoholic fatty liver disease. |
| format |
article |
| author |
Antonio Rivero-Juárez Angela Camacho Nicolás Merchante Inés Pérez-Camacho Juan Macias Carmen Ortiz-Garcia Celia Cifuentes Julián Torre-Cisneros José Peña Juan A Pineda Antonio Rivero Grupo para el estudio de las hepatitis vı´ricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI) |
| author_facet |
Antonio Rivero-Juárez Angela Camacho Nicolás Merchante Inés Pérez-Camacho Juan Macias Carmen Ortiz-Garcia Celia Cifuentes Julián Torre-Cisneros José Peña Juan A Pineda Antonio Rivero Grupo para el estudio de las hepatitis vı´ricas (HEPAVIR) de la Sociedad Andaluza de Enfermedades Infecciosas (SAEI) |
| author_sort |
Antonio Rivero-Juárez |
| title |
Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| title_short |
Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| title_full |
Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| title_fullStr |
Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| title_full_unstemmed |
Incidence of liver damage of uncertain origin in HIV patients not co-infected with HCV/HBV. |
| title_sort |
incidence of liver damage of uncertain origin in hiv patients not co-infected with hcv/hbv. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/b204072b79b4432392831e20a0c0ecc8 |
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