Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension

Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension

Pinakin Gunvant1, Lucia Porsia2, Russell J Watkins3, Henrietta Bayliss-Brown2, David C Broadway21Department of Research, Southern College of Optometry, Memphis, TN, USA; 2Department of Ophthalmology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK; 3Department of Pathology, Algernon F...

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Autores principales: Pinakin Gunvant, Lucia Porsia, Russell J Watkins, Henrietta Bayliss-Brown, David C Broadway
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2008
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/b206a50eb30c4a3da941649c9ba475d4
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spelling oai:doaj.org-article:b206a50eb30c4a3da941649c9ba475d42021-12-02T04:40:33ZRelationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension1177-54671177-5483https://doaj.org/article/b206a50eb30c4a3da941649c9ba475d42008-10-01T00:00:00Zhttp://www.dovepress.com/relationships-between-central-corneal-thickness-and-optic-disc-topogra-a2366https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Pinakin Gunvant1, Lucia Porsia2, Russell J Watkins3, Henrietta Bayliss-Brown2, David C Broadway21Department of Research, Southern College of Optometry, Memphis, TN, USA; 2Department of Ophthalmology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK; 3Department of Pathology, Algernon Firth Buildings, Leeds General Infirmary, Leeds, UKPurpose: To identify relationships between central corneal thickness (CCT) and optic disc topography, as determined by scanning laser ophthalmoscopy (SLO), for patients seen in a specialist glaucoma service.Methods: 272 eyes of 144 patients with primary open angle glaucoma (POAG; n = 71), normal tension glaucoma (NTG; n = 50), ocular hypertension (OH; n = 48) and those considered to be suspicious for glaucoma (GS; n = 103) underwent ultrasonic pachymetry and optic disc topography by SLO. Correlations between CCT and SLO parameter values were identified. A Bonferroni correction for multiple comparisons was performed and a p value of 0.0042 was considered significant.Results: Mean CCT values were 533 μm (POAG), 530 μm (NTG), 550 μm (GS), and 565 μm (OH). As a group the GS and OH eyes had signifi cantly thicker CCT values than eyes with POAG. In addition, the NTG eyes had signifi cantly thinner CCT values than GS and OH eyes. Overall multiple SLO parameters correlated with CCT even after accounting for co-variance with age, refraction and inclusion of both eyes. Sub-group analysis indicated that ‘optic disc rim area’ positively correlated with CCT (r = 0.378) and ‘cup to disc area ratio’ negatively correlated with CCT (r = −0.370) in the POAG group. In the GS group the parameter ‘area below reference’ (a measure of cup volume) and ‘mean cup depth’ had negative correlations with CCT (r = −0.297 and −0.323) indicating that eyes with thinner than average corneal thickness measurements had larger and deeper cups.Conclusion: Thinner corneas appear to be associated with larger and deeper optic disc cups in the eyes of patients seen in a specialist glaucoma service.Keywords: central corneal thickness, optic disc topography, optic disc compliance, glaucoma Pinakin GunvantLucia PorsiaRussell J WatkinsHenrietta Bayliss-BrownDavid C BroadwayDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 3, Pp 591-599 (2008)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Pinakin Gunvant
Lucia Porsia
Russell J Watkins
Henrietta Bayliss-Brown
David C Broadway
Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
description Pinakin Gunvant1, Lucia Porsia2, Russell J Watkins3, Henrietta Bayliss-Brown2, David C Broadway21Department of Research, Southern College of Optometry, Memphis, TN, USA; 2Department of Ophthalmology, Norfolk and Norwich University Hospital NHS Trust, Norwich, UK; 3Department of Pathology, Algernon Firth Buildings, Leeds General Infirmary, Leeds, UKPurpose: To identify relationships between central corneal thickness (CCT) and optic disc topography, as determined by scanning laser ophthalmoscopy (SLO), for patients seen in a specialist glaucoma service.Methods: 272 eyes of 144 patients with primary open angle glaucoma (POAG; n = 71), normal tension glaucoma (NTG; n = 50), ocular hypertension (OH; n = 48) and those considered to be suspicious for glaucoma (GS; n = 103) underwent ultrasonic pachymetry and optic disc topography by SLO. Correlations between CCT and SLO parameter values were identified. A Bonferroni correction for multiple comparisons was performed and a p value of 0.0042 was considered significant.Results: Mean CCT values were 533 μm (POAG), 530 μm (NTG), 550 μm (GS), and 565 μm (OH). As a group the GS and OH eyes had signifi cantly thicker CCT values than eyes with POAG. In addition, the NTG eyes had signifi cantly thinner CCT values than GS and OH eyes. Overall multiple SLO parameters correlated with CCT even after accounting for co-variance with age, refraction and inclusion of both eyes. Sub-group analysis indicated that ‘optic disc rim area’ positively correlated with CCT (r = 0.378) and ‘cup to disc area ratio’ negatively correlated with CCT (r = −0.370) in the POAG group. In the GS group the parameter ‘area below reference’ (a measure of cup volume) and ‘mean cup depth’ had negative correlations with CCT (r = −0.297 and −0.323) indicating that eyes with thinner than average corneal thickness measurements had larger and deeper cups.Conclusion: Thinner corneas appear to be associated with larger and deeper optic disc cups in the eyes of patients seen in a specialist glaucoma service.Keywords: central corneal thickness, optic disc topography, optic disc compliance, glaucoma
format article
author Pinakin Gunvant
Lucia Porsia
Russell J Watkins
Henrietta Bayliss-Brown
David C Broadway
author_facet Pinakin Gunvant
Lucia Porsia
Russell J Watkins
Henrietta Bayliss-Brown
David C Broadway
author_sort Pinakin Gunvant
title Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
title_short Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
title_full Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
title_fullStr Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
title_full_unstemmed Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
title_sort relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertension
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/b206a50eb30c4a3da941649c9ba475d4
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