Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2

Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2

Abstract Reduction of elastin in the skin causes various skin diseases as well as wrinkles and sagging with aging. Sialidase is a hydrolase that cleaves a sialic acid residue from sialoglycoconjugate. Cleavage of sialic acid from microfibrils by the sialidase isozyme Neu1 facilitates elastic fiber a...

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Main Authors: Akira Minami, Yuka Fujita, Jun Goto, Ayano Iuchi, Kosei Fujita, Yasuyo Mikami, Mako Shiratori, Ami Ishii, Samir Mitragotri, Yasunori Iwao, Hiroaki Kanazawa, Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/b206dd55f73d4226b1ced499d9b7d30c
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