Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.

Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. Recent studies have showed that microRNAs (miRNAs), small noncoding RNAs of length ranging from 18-23 nucleotides (nt) participate in host-pathogen interaction networks; however, whether or not miRNAs are i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jia-zeng Sun, Jigui Wang, Daoli Yuan, Shuang Wang, Zhili Li, Bao Yi, Yaping Mao, Qiang Hou, Weiquan Liu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b207706f357747da95387b9b998c70ca
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:b207706f357747da95387b9b998c70ca
record_format	dspace
spelling	oai:doaj.org-article:b207706f357747da95387b9b998c70ca2021-11-18T08:42:31ZCellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.1932-620310.1371/journal.pone.0081515https://doaj.org/article/b207706f357747da95387b9b998c70ca2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24349084/?tool=EBIhttps://doaj.org/toc/1932-6203Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. Recent studies have showed that microRNAs (miRNAs), small noncoding RNAs of length ranging from 18-23 nucleotides (nt) participate in host-pathogen interaction networks; however, whether or not miRNAs are involved in MEV infection has not been reported. Our study revealed that miRNA miR-181b inhibited replication of MEV in the feline kidney (F81) cell line by targeting the MEV non-structural protein 1 (NS1) messenger RNA (mRNA) coding region, resulting in NS1 translational repression, while MEV infection reduced miR-181b expression. This is the first description of cellular miRNAs modulating MEV infection in F81 cells, providing further insight into the mechanisms of viral infection, and may be useful in development of naturally-occurring miRNAs antiviral strategies.Jia-zeng SunJigui WangDaoli YuanShuang WangZhili LiBao YiYaping MaoQiang HouWeiquan LiuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e81515 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jia-zeng Sun Jigui Wang Daoli Yuan Shuang Wang Zhili Li Bao Yi Yaping Mao Qiang Hou Weiquan Liu Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
description	Mink enteritis virus (MEV) is one of the most important viral pathogens in the mink industry. Recent studies have showed that microRNAs (miRNAs), small noncoding RNAs of length ranging from 18-23 nucleotides (nt) participate in host-pathogen interaction networks; however, whether or not miRNAs are involved in MEV infection has not been reported. Our study revealed that miRNA miR-181b inhibited replication of MEV in the feline kidney (F81) cell line by targeting the MEV non-structural protein 1 (NS1) messenger RNA (mRNA) coding region, resulting in NS1 translational repression, while MEV infection reduced miR-181b expression. This is the first description of cellular miRNAs modulating MEV infection in F81 cells, providing further insight into the mechanisms of viral infection, and may be useful in development of naturally-occurring miRNAs antiviral strategies.
format	article
author	Jia-zeng Sun Jigui Wang Daoli Yuan Shuang Wang Zhili Li Bao Yi Yaping Mao Qiang Hou Weiquan Liu
author_facet	Jia-zeng Sun Jigui Wang Daoli Yuan Shuang Wang Zhili Li Bao Yi Yaping Mao Qiang Hou Weiquan Liu
author_sort	Jia-zeng Sun
title	Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
title_short	Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
title_full	Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
title_fullStr	Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
title_full_unstemmed	Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
title_sort	cellular microrna mir-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/b207706f357747da95387b9b998c70ca
work_keys_str_mv	AT jiazengsun cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT jiguiwang cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT daoliyuan cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT shuangwang cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT zhilili cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT baoyi cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT yapingmao cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT qianghou cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation AT weiquanliu cellularmicrornamir181binhibitsreplicationofminkenteritisvirusbyrepressionofnonstructuralprotein1translation
_version_	1718421464623874048

Cellular microRNA miR-181b inhibits replication of mink enteritis virus by repression of non-structural protein 1 translation.

Ejemplares similares