Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance

Bacterial vaginosis (BV) is the most common infectious non-inflammatory disease in women of reproductive age. The key feature of BV is that in the absence of a specific pathogen, the disease develops against the background of vaginal biotope dysbiosis. According to the opinion of some authors, init...

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Autores principales:	N. M. Voropaeva, N. L. Belkova, J. M. Nemchenko, E. V. Grigorova, I. N. Danusevich
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2021
Materias:	bacterial vaginosis polymicrobial infection gardnerella vaginalis atopobium vaginae mobiluncus spp. prevotella spp. bacterial biofilms Science Q
Acceso en línea:	https://doaj.org/article/b20bc5abc74c4c2e9c0ec01bbd2ded3d
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spelling	oai:doaj.org-article:b20bc5abc74c4c2e9c0ec01bbd2ded3d2021-11-23T06:14:46ZMicroorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance2541-94202587-959610.29413/ABS.2021-6.3.2https://doaj.org/article/b20bc5abc74c4c2e9c0ec01bbd2ded3d2021-08-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/2842https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Bacterial vaginosis (BV) is the most common infectious non-inflammatory disease in women of reproductive age. The key feature of BV is that in the absence of a specific pathogen, the disease develops against the background of vaginal biotope dysbiosis. According to the opinion of some authors, initially, the main role of BV in the pathogenesis was assigned to the species G. vaginalis. However, using of molecular methods made it possible to significantly expand the range of microorganisms found in women with BV, and to identify Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Prevotella spp. as the primary causative agents of BV. A number of studies have confirmed the sexual transmission of BV pathogens, with a new sexual partner being significant risk factors for episodic BV, and sexual contact with the same partner without using barrier methods of contraception for recurrent BV. At the same time, BV-associated bacterias rarely exist as planktonic forms of one species, more often, they thrive in complex polymicrobial communities surrounded by an extracellular matrix, the so-called biofilms. In patients with BV, biofilms are detected in 90% of cases. G. vaginalis and Prevotella bivia are widespread in women with BV and, being the primary colonizers, create a bacterial biofilm, to which secondary colonizers can subsequently join, including A. vaginae, Sneathia spp. and potentially other BVABs. The resistance of bacterias in the biofilm to antimicrobial drugs is 1000 times higher than of planktonic forms, which can lead to chronicity of the infectious process and torpid course of the disease.The aim of this review was analyzing of modern studies on the prevalence, characteristics of opportunistic microorganisms associated with BV, to present their clinical and diagnostic significance and role in the pathogenesis of diseases.N. M. VoropaevaN. L. BelkovaJ. M. NemchenkoE. V. GrigorovaI. N. DanusevichScientific Сentre for Family Health and Human Reproduction Problemsarticlebacterial vaginosispolymicrobial infectiongardnerella vaginalisatopobium vaginaemobiluncus spp.prevotella spp.bacterial biofilmsScienceQRUActa Biomedica Scientifica, Vol 6, Iss 3, Pp 17-30 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	bacterial vaginosis polymicrobial infection gardnerella vaginalis atopobium vaginae mobiluncus spp. prevotella spp. bacterial biofilms Science Q
spellingShingle	bacterial vaginosis polymicrobial infection gardnerella vaginalis atopobium vaginae mobiluncus spp. prevotella spp. bacterial biofilms Science Q N. M. Voropaeva N. L. Belkova J. M. Nemchenko E. V. Grigorova I. N. Danusevich Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
description	Bacterial vaginosis (BV) is the most common infectious non-inflammatory disease in women of reproductive age. The key feature of BV is that in the absence of a specific pathogen, the disease develops against the background of vaginal biotope dysbiosis. According to the opinion of some authors, initially, the main role of BV in the pathogenesis was assigned to the species G. vaginalis. However, using of molecular methods made it possible to significantly expand the range of microorganisms found in women with BV, and to identify Gardnerella vaginalis, Atopobium vaginae, Mobiluncus spp., Prevotella spp. as the primary causative agents of BV. A number of studies have confirmed the sexual transmission of BV pathogens, with a new sexual partner being significant risk factors for episodic BV, and sexual contact with the same partner without using barrier methods of contraception for recurrent BV. At the same time, BV-associated bacterias rarely exist as planktonic forms of one species, more often, they thrive in complex polymicrobial communities surrounded by an extracellular matrix, the so-called biofilms. In patients with BV, biofilms are detected in 90% of cases. G. vaginalis and Prevotella bivia are widespread in women with BV and, being the primary colonizers, create a bacterial biofilm, to which secondary colonizers can subsequently join, including A. vaginae, Sneathia spp. and potentially other BVABs. The resistance of bacterias in the biofilm to antimicrobial drugs is 1000 times higher than of planktonic forms, which can lead to chronicity of the infectious process and torpid course of the disease.The aim of this review was analyzing of modern studies on the prevalence, characteristics of opportunistic microorganisms associated with BV, to present their clinical and diagnostic significance and role in the pathogenesis of diseases.
format	article
author	N. M. Voropaeva N. L. Belkova J. M. Nemchenko E. V. Grigorova I. N. Danusevich
author_facet	N. M. Voropaeva N. L. Belkova J. M. Nemchenko E. V. Grigorova I. N. Danusevich
author_sort	N. M. Voropaeva
title	Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
title_short	Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
title_full	Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
title_fullStr	Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
title_full_unstemmed	Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
title_sort	microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2021
url	https://doaj.org/article/b20bc5abc74c4c2e9c0ec01bbd2ded3d
work_keys_str_mv	AT nmvoropaeva microorganismsassociatedwithbacterialvaginosisdiversityandclinicalanddiagnosticsignificance AT nlbelkova microorganismsassociatedwithbacterialvaginosisdiversityandclinicalanddiagnosticsignificance AT jmnemchenko microorganismsassociatedwithbacterialvaginosisdiversityandclinicalanddiagnosticsignificance AT evgrigorova microorganismsassociatedwithbacterialvaginosisdiversityandclinicalanddiagnosticsignificance AT indanusevich microorganismsassociatedwithbacterialvaginosisdiversityandclinicalanddiagnosticsignificance
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Microorganisms associated with bacterial vaginosis: diversity and clinical and diagnostic significance

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