Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism

Abstract The aim of our study was to asses the long-term prognostic impact of post-acute, pre-discharge echocardiographic assessment of right ventricular (RV) dysfunction in patients with low- and intermediate-risk pulmonary embolism (PE). Consecutive patients with acute PE underwent post-acute, pre...

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Autores principales:	Nataša Kokalj, Matija Kozak, Borut Jug
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b212824bece7473e9b3840dcad406705
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spelling	oai:doaj.org-article:b212824bece7473e9b3840dcad4067052021-12-02T13:24:36ZPost-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism10.1038/s41598-021-82038-12045-2322https://doaj.org/article/b212824bece7473e9b3840dcad4067052021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82038-1https://doaj.org/toc/2045-2322Abstract The aim of our study was to asses the long-term prognostic impact of post-acute, pre-discharge echocardiographic assessment of right ventricular (RV) dysfunction in patients with low- and intermediate-risk pulmonary embolism (PE). Consecutive patients with acute PE underwent post-acute, pre-discharge echocardiographic assessment of RV dysfunction (defined by: RV dilation, tricuspid anulus peak systolic excursion, or tricuspid regurgitation systolic velocity). A Cox multivariate survival mode was constructed to determine the prognostic impact of post-acute, pred-discharge RV dysfunction on all-cause mortality. 615 patients were included: 330 (54%) women, mean age 64 ± 18 years, 265 (43.1%) with post-acute, predischarge RV dysfunction. During follow-up (median 1068 days), 88 (14.3%) patients died. On Cox multivariate analyis, pre-discharge post-acute tricuspid regurgitation systolic velocity emerged as the only independent echocardiographic predictor of mortality (HR 1.73 for every 1 m/s increase; 95% confidence interval 1.033–2.897; p = 0.037). RV dysfunction persists in almost one half of PE patients in the post-acute phase on pre-discharge echocardiography; however, only tricuspid regurgitation systolic velocity independently predicts long-term prognosis.Nataša KokaljMatija KozakBorut JugNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nataša Kokalj Matija Kozak Borut Jug Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
description	Abstract The aim of our study was to asses the long-term prognostic impact of post-acute, pre-discharge echocardiographic assessment of right ventricular (RV) dysfunction in patients with low- and intermediate-risk pulmonary embolism (PE). Consecutive patients with acute PE underwent post-acute, pre-discharge echocardiographic assessment of RV dysfunction (defined by: RV dilation, tricuspid anulus peak systolic excursion, or tricuspid regurgitation systolic velocity). A Cox multivariate survival mode was constructed to determine the prognostic impact of post-acute, pred-discharge RV dysfunction on all-cause mortality. 615 patients were included: 330 (54%) women, mean age 64 ± 18 years, 265 (43.1%) with post-acute, predischarge RV dysfunction. During follow-up (median 1068 days), 88 (14.3%) patients died. On Cox multivariate analyis, pre-discharge post-acute tricuspid regurgitation systolic velocity emerged as the only independent echocardiographic predictor of mortality (HR 1.73 for every 1 m/s increase; 95% confidence interval 1.033–2.897; p = 0.037). RV dysfunction persists in almost one half of PE patients in the post-acute phase on pre-discharge echocardiography; however, only tricuspid regurgitation systolic velocity independently predicts long-term prognosis.
format	article
author	Nataša Kokalj Matija Kozak Borut Jug
author_facet	Nataša Kokalj Matija Kozak Borut Jug
author_sort	Nataša Kokalj
title	Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
title_short	Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
title_full	Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
title_fullStr	Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
title_full_unstemmed	Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
title_sort	post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b212824bece7473e9b3840dcad406705
work_keys_str_mv	AT natasakokalj postacutepredischargeechocardiographyinthelongtermprognosticassessmentofpulmonarythrombembolism AT matijakozak postacutepredischargeechocardiographyinthelongtermprognosticassessmentofpulmonarythrombembolism AT borutjug postacutepredischargeechocardiographyinthelongtermprognosticassessmentofpulmonarythrombembolism
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Post-acute pre-discharge echocardiography in the long-term prognostic assessment of pulmonary thrombembolism

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