Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis

Abstract Homing of circulating tumour cells (CTC) at distant sites represents a critical event in metastasis dissemination. In addition to physical entrapment, probably responsible of the majority of the homing events, the vascular system provides with geometrical factors that govern the flow biomec...

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Autores principales:	Carlos Casas-Arozamena, Alberto Otero-Cacho, Bastian Carnero, Cristina Almenglo, Maria Aymerich, Lorena Alonso-Alconada, Alba Ferreiros, Alicia Abalo, Carmen Bao-Varela, Maria Teresa Flores-Arias, Ezequiel Alvarez, Alberto P. Munuzuri, Miguel Abal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b213273ac6354f659c8193cbc71ac4c0
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spelling	oai:doaj.org-article:b213273ac6354f659c8193cbc71ac4c02021-12-05T12:12:47ZHaemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis10.1038/s41598-021-02482-x2045-2322https://doaj.org/article/b213273ac6354f659c8193cbc71ac4c02021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02482-xhttps://doaj.org/toc/2045-2322Abstract Homing of circulating tumour cells (CTC) at distant sites represents a critical event in metastasis dissemination. In addition to physical entrapment, probably responsible of the majority of the homing events, the vascular system provides with geometrical factors that govern the flow biomechanics and impact on the fate of the CTC. Here we mathematically explored the distribution of velocities and the corresponding streamlines at the bifurcations of large blood vessel and characterized an area of low-velocity at the carina of bifurcation that favours the residence of CTC. In addition to this fluid physics effect, the adhesive capabilities of the CTC provide with a biological competitive advantage resulting in a marginal but systematic arrest as evidenced by dynamic in vitro recirculation in Y-microchannels and by perfusion in in vivo mice models. Our results also demonstrate that viscosity, as a main determinant of the Reynolds number that define flow biomechanics, may be modulated to limit or impair CTC accumulation at the bifurcation of blood vessels, in agreement with the apparent positive effect observed in the clinical setting by anticoagulants in advanced oncology disease.Carlos Casas-ArozamenaAlberto Otero-CachoBastian CarneroCristina AlmengloMaria AymerichLorena Alonso-AlconadaAlba FerreirosAlicia AbaloCarmen Bao-VarelaMaria Teresa Flores-AriasEzequiel AlvarezAlberto P. MunuzuriMiguel AbalNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Casas-Arozamena Alberto Otero-Cacho Bastian Carnero Cristina Almenglo Maria Aymerich Lorena Alonso-Alconada Alba Ferreiros Alicia Abalo Carmen Bao-Varela Maria Teresa Flores-Arias Ezequiel Alvarez Alberto P. Munuzuri Miguel Abal Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
description	Abstract Homing of circulating tumour cells (CTC) at distant sites represents a critical event in metastasis dissemination. In addition to physical entrapment, probably responsible of the majority of the homing events, the vascular system provides with geometrical factors that govern the flow biomechanics and impact on the fate of the CTC. Here we mathematically explored the distribution of velocities and the corresponding streamlines at the bifurcations of large blood vessel and characterized an area of low-velocity at the carina of bifurcation that favours the residence of CTC. In addition to this fluid physics effect, the adhesive capabilities of the CTC provide with a biological competitive advantage resulting in a marginal but systematic arrest as evidenced by dynamic in vitro recirculation in Y-microchannels and by perfusion in in vivo mice models. Our results also demonstrate that viscosity, as a main determinant of the Reynolds number that define flow biomechanics, may be modulated to limit or impair CTC accumulation at the bifurcation of blood vessels, in agreement with the apparent positive effect observed in the clinical setting by anticoagulants in advanced oncology disease.
format	article
author	Carlos Casas-Arozamena Alberto Otero-Cacho Bastian Carnero Cristina Almenglo Maria Aymerich Lorena Alonso-Alconada Alba Ferreiros Alicia Abalo Carmen Bao-Varela Maria Teresa Flores-Arias Ezequiel Alvarez Alberto P. Munuzuri Miguel Abal
author_facet	Carlos Casas-Arozamena Alberto Otero-Cacho Bastian Carnero Cristina Almenglo Maria Aymerich Lorena Alonso-Alconada Alba Ferreiros Alicia Abalo Carmen Bao-Varela Maria Teresa Flores-Arias Ezequiel Alvarez Alberto P. Munuzuri Miguel Abal
author_sort	Carlos Casas-Arozamena
title	Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
title_short	Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
title_full	Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
title_fullStr	Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
title_full_unstemmed	Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
title_sort	haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b213273ac6354f659c8193cbc71ac4c0
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Haemodynamic-dependent arrest of circulating tumour cells at large blood vessel bifurcations as new model for metastasis

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