Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice

This study was performed to determine the effects of bacteriocin-producing and non-bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice. Two P. acidilactici strains with antibacterial activity (P. acidilactici CCFM28 and CCFM18) were obtaine...

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Autores principales:	Yiteng Qiao, Zhichang Qiu, Fengwei Tian, Leilei Yu, Jianxin Zhao, Hao Zhang, Qixiao Zhai, Wei Chen
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Pediococcus acidilactici Bacteriocin Immune system Intestinal flora Regulation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/b2187de066c142d1b70d978b47c23fcd
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id	oai:doaj.org-article:b2187de066c142d1b70d978b47c23fcd
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spelling	oai:doaj.org-article:b2187de066c142d1b70d978b47c23fcd2021-11-28T04:31:55ZEffect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice2213-453010.1016/j.fshw.2021.11.008https://doaj.org/article/b2187de066c142d1b70d978b47c23fcd2022-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S221345302100104Xhttps://doaj.org/toc/2213-4530This study was performed to determine the effects of bacteriocin-producing and non-bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice. Two P. acidilactici strains with antibacterial activity (P. acidilactici CCFM28 and CCFM18) were obtained based on the inhibition-zone assay. The produced components were identified as bacteriocins through protease treatment, pH adjustment and hydrogen peroxide treatment. Bacteriocin-producing and non-bacteriocin-producing P. acidilactici strains (P. acidilactici CCFM28, CCFM18 and NT17-3) caused significant changes in serum immune factors and intestinal flora of normal mice. After 14 days of intervention, the relative abundance of Firmicutes was significantly decreased, but that of Proteobacteria was significantly increased at the phylum level. At the genus level, the administration of three P. acidilactici strains resulted in the downregulation of Blautia and the upregulation of Ruminococcus and Lactobacillus. Furthermore, there were also different regulations on some probiotic strains, such as Bifidobacterium, Coprococcus and Akkermansia, which were closely related to the antibacterial ability of the bacteriocin and the type of strain. The results indicated that the intervention of different P. acidilactici strains could differently change the structure of intestinal flora in normal mice, which provided theoretical guidance for the selective use of bacteriocin-producing strains for health regulation in the future.Yiteng QiaoZhichang QiuFengwei TianLeilei YuJianxin ZhaoHao ZhangQixiao ZhaiWei ChenKeAi Communications Co., Ltd.articlePediococcus acidilacticiBacteriocinImmune systemIntestinal floraRegulationNutrition. Foods and food supplyTX341-641ENFood Science and Human Wellness, Vol 11, Iss 2, Pp 238-246 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pediococcus acidilactici Bacteriocin Immune system Intestinal flora Regulation Nutrition. Foods and food supply TX341-641
spellingShingle	Pediococcus acidilactici Bacteriocin Immune system Intestinal flora Regulation Nutrition. Foods and food supply TX341-641 Yiteng Qiao Zhichang Qiu Fengwei Tian Leilei Yu Jianxin Zhao Hao Zhang Qixiao Zhai Wei Chen Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
description	This study was performed to determine the effects of bacteriocin-producing and non-bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice. Two P. acidilactici strains with antibacterial activity (P. acidilactici CCFM28 and CCFM18) were obtained based on the inhibition-zone assay. The produced components were identified as bacteriocins through protease treatment, pH adjustment and hydrogen peroxide treatment. Bacteriocin-producing and non-bacteriocin-producing P. acidilactici strains (P. acidilactici CCFM28, CCFM18 and NT17-3) caused significant changes in serum immune factors and intestinal flora of normal mice. After 14 days of intervention, the relative abundance of Firmicutes was significantly decreased, but that of Proteobacteria was significantly increased at the phylum level. At the genus level, the administration of three P. acidilactici strains resulted in the downregulation of Blautia and the upregulation of Ruminococcus and Lactobacillus. Furthermore, there were also different regulations on some probiotic strains, such as Bifidobacterium, Coprococcus and Akkermansia, which were closely related to the antibacterial ability of the bacteriocin and the type of strain. The results indicated that the intervention of different P. acidilactici strains could differently change the structure of intestinal flora in normal mice, which provided theoretical guidance for the selective use of bacteriocin-producing strains for health regulation in the future.
format	article
author	Yiteng Qiao Zhichang Qiu Fengwei Tian Leilei Yu Jianxin Zhao Hao Zhang Qixiao Zhai Wei Chen
author_facet	Yiteng Qiao Zhichang Qiu Fengwei Tian Leilei Yu Jianxin Zhao Hao Zhang Qixiao Zhai Wei Chen
author_sort	Yiteng Qiao
title	Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
title_short	Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
title_full	Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
title_fullStr	Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
title_full_unstemmed	Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
title_sort	effect of bacteriocin-producing pediococcus acidilactici strains on the immune system and intestinal flora of normal mice
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/b2187de066c142d1b70d978b47c23fcd
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Effect of bacteriocin-producing Pediococcus acidilactici strains on the immune system and intestinal flora of normal mice

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