Conformational changes of fibrinogen in dispersed carbon nanotubes

Sung Jean Park,1 Dongwoo Khang21College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, South Korea; 2School of Nano and Advanced Materials Science Engineering and Center for PRC and RIGET, Gyeongsang National University, Jinju, South KoreaAbstract: The conformational changes of plasma protein s...

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Autores principales:	Park SJ, Khang D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/b21a7a69d34841c4bd27202e8d756e70
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spelling	oai:doaj.org-article:b21a7a69d34841c4bd27202e8d756e702021-12-02T06:46:22ZConformational changes of fibrinogen in dispersed carbon nanotubes1176-91141178-2013https://doaj.org/article/b21a7a69d34841c4bd27202e8d756e702012-08-01T00:00:00Zhttp://www.dovepress.com/conformational-changes-of-fibrinogen-in-dispersed-carbon-nanotubes-a10619https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Sung Jean Park,1 Dongwoo Khang21College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, South Korea; 2School of Nano and Advanced Materials Science Engineering and Center for PRC and RIGET, Gyeongsang National University, Jinju, South KoreaAbstract: The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Also, elevation of carbon nanotube density can alter the secondary structures (ie, helices and beta sheets) of fibrinogen. Furthermore, fibrinogen that had been in contact with the nanoparticle material demonstrated a different pattern of heat denaturation compared with free fibrinogen as a result of a variation in hydrophilicity and concentration of carbon nanotubes. Considering the importance of interactions between carbon nanotubes and plasma proteins in the drug delivery system, this study elucidated the correlation between nanoscale physiochemical material properties of carbon nanotubes and associated structural changes in fibrinogen.Keywords: carbon nanotubes, fibrinogen, nanotoxicity, conformational change, denaturationPark SJKhang DDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 4325-4333 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Park SJ Khang D Conformational changes of fibrinogen in dispersed carbon nanotubes
description	Sung Jean Park,1 Dongwoo Khang21College of Pharmacy, Gachon University, Yeonsu-gu, Incheon, South Korea; 2School of Nano and Advanced Materials Science Engineering and Center for PRC and RIGET, Gyeongsang National University, Jinju, South KoreaAbstract: The conformational changes of plasma protein structures in response to carbon nanotubes are critical for determining the nanotoxicity and blood coagulation effects of carbon nanotubes. In this study, we identified that the functional intensity of carboxyl groups on carbon nanotubes, which correspond to the water dispersity or hydrophilicity of carbon nanotubes, can induce conformational changes in the fibrinogen domains. Also, elevation of carbon nanotube density can alter the secondary structures (ie, helices and beta sheets) of fibrinogen. Furthermore, fibrinogen that had been in contact with the nanoparticle material demonstrated a different pattern of heat denaturation compared with free fibrinogen as a result of a variation in hydrophilicity and concentration of carbon nanotubes. Considering the importance of interactions between carbon nanotubes and plasma proteins in the drug delivery system, this study elucidated the correlation between nanoscale physiochemical material properties of carbon nanotubes and associated structural changes in fibrinogen.Keywords: carbon nanotubes, fibrinogen, nanotoxicity, conformational change, denaturation
format	article
author	Park SJ Khang D
author_facet	Park SJ Khang D
author_sort	Park SJ
title	Conformational changes of fibrinogen in dispersed carbon nanotubes
title_short	Conformational changes of fibrinogen in dispersed carbon nanotubes
title_full	Conformational changes of fibrinogen in dispersed carbon nanotubes
title_fullStr	Conformational changes of fibrinogen in dispersed carbon nanotubes
title_full_unstemmed	Conformational changes of fibrinogen in dispersed carbon nanotubes
title_sort	conformational changes of fibrinogen in dispersed carbon nanotubes
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/b21a7a69d34841c4bd27202e8d756e70
work_keys_str_mv	AT parksj conformationalchangesoffibrinogenindispersedcarbonnanotubes AT khangd conformationalchangesoffibrinogenindispersedcarbonnanotubes
_version_	1718399773398007808

Conformational changes of fibrinogen in dispersed carbon nanotubes

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